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Biomedical subjects

I Christensen

Publications and source records attributed to I Christensen.

46 records · Page 3Linked to original sources
PubMed1976

Radioimmunoassay of human calcitonin in serum and tissue from healthy individuals and patients with medullary carcinoma of the thyroid gland.

A specific radioimmunological method for measurement of immunoreactive calcitonin (iCT) in human serum and tissue is decribed. Of healthy individuals of both sexes, 85% had measurable iCT in serum (mean, 0.23 ng/ml). Of 29 patients who had received treatment for medullary carcinoma of the thyroid gland (MCT), 19 had increased serum iCT (0.60 ng/ml to 205 ng/ml). Elevated serum iCT was also found preoperatively in 2 MCT patients. Eleven of the patients with abnormal elevations of serum iCT were alive 4 to 13 years after the operation. Concentration of iCT in extracts from MCT varied from 0.5 to 540 ng/ml wet weight. The diagnostic value of this method and its importance for pre- and post-operative evaluation of these patients are improved by the use of selective venous catheterization in basal state and during stimulation of CT secretion.

Adult↗
PubMed1975

Early and late effects of irradiation for seminoma testis on the number of blood lymphocytes and their B and T subpopulations.

High voltage irradiation of the iliac and paraaortic lymph nodes for seminoma testis induces a grave, acute blood lymphocytopenia. A major part of this effect is probably caused by irradiation of the blood. Indications are presented that B lymphocytes are more gravely affected than T lymphocytes. It is possible that the treatment leaves a relatively radioresistant subpopulation of lymphocytes, mostly consisting of T lymphocytes. The total number of blood lymphocytes is normalized five to ten years after treatment. Six months after treatment the percentage of B lymphocytes is clearly higher than normal, remaining so for the first three years. The percentage of T lymphocytes is unchanged both during therapy and at all intervals thereafter. The results therefore indicate that the number of B lymphocytes is more rapidly normalized after radiotherapy than that of T lymphocytes, and that the post-irradiation lymphocytopenia is mainly a T lymphocytopenia. However, this shift in B/T lymphocyte ratio is not permanent, being completely or nearly normalized after ten years. This pattern of regeneration seems to be essentially the same in patients who have received additional treatment to the mediastinum, probably meaning that the thymus has only a marginal influence on the regeneration of T lymphocytes in the adult organism. It is possible that the rapid recovery of B lymphocytes relates to the ability of the bone marrow to extend into non-irradiated parts of the skeleton after radiation destruction.

Adult↗
PubMedDate not supplied

Clinical trial of intensive muscle training for chronic low back pain.

105 patients who had chronic low back pain without clinical signs of lumbar nerve root compression or radiological evidence of spondylolysis or osteomalacia were randomised to three treatments: 30 sessions of intensive dynamic back extensor exercises over three months; a similar programme at one-fifth the exercise intensity; or one month of thermotherapy, massage, and mild exercises. The results consistently favoured intensive exercise, which had no adverse effects. Since these exercises can be conducted in groups, the intensive programme is no more costly than conventional strategies that require individual attention.

Activities of Daily Living↗
PubMedDate not supplied

Sarcoma following irradiation for breast cancer. Report of three unusual cases including one malignant mesenchymoma of bone.

Three cases of sarcoma developing after irradiation for breast cancer are reported. A malignant mesenchymoma in the sternum--a combination of osteogenic sarcoma and rhabdomyosarcoma--is the first documented case of its kind occurring after radiation therapy. Of the other two tumors one was an extraskeletal osteogenic sarcoma in the soft tissues of the thoracic wall and one a rhabdomyosarcoma in the axilla.

Adult↗
PubMedDate not supplied

Photopheresis therapy of cutaneous T-cell lymphoma: the Yale-New Haven Hospital experience.

Over the past two years, the photopheresis treatment program at Yale-New Haven Hospital has treated 32 patients with cutaneous T-cell lymphoma. There were 19 erythrodermic patients who had photopheresis as their first systemic therapy. Five of these cleared 75 percent of their skin and the majority of erythrodermics achieved an improved quality of life. Those with best responses were treated earlier in the course of their disease and had more normal proportions of CD4 and CD8 subsets when compared to patients with poor responses. In addition, patients with tumor stage disease and those patients in relapse after intensive radio- and chemotherapy were treated with photopheresis. These results demonstrate that photopheresis has a role in the management of cutaneous T-cell lymphoma.

Adult↗