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Biomedical subjects

I E Lalaiants

Publications and source records attributed to I E Lalaiants.

14 recordsLinked to original sources
PubMed1991

[The role of "valine substitution" in oncogene functioning (a hypothesis)].

A hypothesis presented in the paper discusses the role of valine substitution in p21 protein of H-ras, a product of ras family oncogene. The event was followed by a marked decrease in GTPase activity of the protein and alteration of its function in the cell. Recent results of X-ray structural analysis were compared with the model suggested by the authors earlier. The role of valine substitution in sickle-cell anemia held to be a genetic mechanism of protection against malaria is discussed. Based on similarity of valine substitution in p21 protein and hemoglobin, a relationship between certain forms of malignant transformation and malaria at molecular level is suggested.

Anemia, Sickle Cell↗
PubMedDate not supplied

[Biotechnological approaches to the creation of antimalarial vaccines].

The authors analyze the latest data on antigen pattern of malaria Plasmodium at various stages of development and extraction of immunogenic determinants contributing to creation of malaria vaccine. Knowledge of the spectra of Plasmodium antigens and stimulants of humoral and cellular immune response in the body will simplify the search for effective biotechnological vaccines able to provide reliable protection against malaria.

Amino Acid Sequence↗
PubMedDate not supplied

[Valine substitution].

The review deals with analysis of the literature data concerning the importance of valine substitution in certain proteins, namely p21 ras and hemoglobin. A model of the active site of p21 protein is discussed in the light of GTPase activities alterations as a result of monoaminoacid substitution in conservative sites of p21 protein. The established relationship between some forms of transformation and Plasmodium falciparum malaria on the molecular level is shown in a new aspect. The widespread opinion that Hb S is valid as the means of malaria resistance is questioned in terms of new molecular data.

Amino Acid Sequence↗
PubMedDate not supplied

[Pharmacologic aspects of AIDS].

The recent findings of the research on the acquired immune deficiency syndrome (AIDS) are reviewed. They provide information about the epidemiological, genetical and morphological features of the human immunodeficiency virus (HIV) and HIV-like viruses, in particular, HTLB-1. Special attention was paid to the pharmacological aspects of preventing AIDS and its spreading among the population. Some new concepts and approaches to the elaboration of therapeutic measures are discussed.

Acquired Immunodeficiency Syndrome↗