[Valine substitution].

I E Lalaiants; L S Milovanova

PubMed · 2196088

[Valine substitution].

Abstract

The review deals with analysis of the literature data concerning the importance of valine substitution in certain proteins, namely p21 ras and hemoglobin. A model of the active site of p21 protein is discussed in the light of GTPase activities alterations as a result of monoaminoacid substitution in conservative sites of p21 protein. The established relationship between some forms of transformation and Plasmodium falciparum malaria on the molecular level is shown in a new aspect. The widespread opinion that Hb S is valid as the means of malaria resistance is questioned in terms of new molecular data.

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Amino Acid Sequence Animals Binding Sites Cell Transformation, Neoplastic Guanosine Triphosphate Humans Hydrolysis Malaria Molecular Sequence Data Mutation Oncogene Protein p21(ras)Phosphorylation Sequence Homology, Nucleic Acid Valine English Abstract Journal Article

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I E Lalaiants, L S Milovanova. [Valine substitution].. https://pubmed.ncbi.nlm.nih.gov/2196088/

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