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Biomedical subjects

I Effendy

Publications and source records attributed to I Effendy.

At least 55 records · Page 3Linked to original sources
PubMed1993

[Topical therapy of onychomycoses with 8% ciclopirox laquer. An open, non-comparative study].

AIM: To investigate the efficacy and tolerability of 8% Ciclopirox-containing nail varnish used for topical treatment of onychomycoses in an open single-center study. METHOD: Forty-seven patients with onychomycoses affecting a finger and/or toe nail were treated with nail varnish containing Ciclopirox once daily for 6 months. The results of treatment were monitored at regular intervals during treatment, and for 6 months after termination of therapy. RESULTS: By the end of treatment, culture for fungi was negative in all the patients investigated; clinical healing was observed in 26 patients (56.5%) and clinical improvement in 13 (28%). In seven patients, however, the clinical findings had hardly changed. By the end of the 6-month follow-up phase, the healing rate (mycological and clinical) was 59.5% (28/47 patients), improvement (mycological healing, clinical improvement) was 12.8% (6/47 patients) and failures (neither mycological nor clinical healing) was 27.7% (13/47 patients). Mild distal subungual onychomycoses and superficial white onychomycoses are the main indications for topical antimycotic treatment. In contrast, extensive distal subungual nail mycoses, proximal subungual and total dystrophic onychomycoses in which the matrix of the nail already appears to be involved, represents the limitations of topical treatment. In addition to the high level of efficacy, which depends upon the extent and form of nail involvement, the substance was very well tolerated; in none of the patients were any side effects observed.

Administration, Topical↗
PubMed1993

[Pincer nail. Conservative correction by attachment of a plastic brace].

In three women, pincer nail deformity of the big toes was successfully treated by means of commercially available plastic braces. The nail plate was first flattened with an electrically driven dermatological grinder, and pliant braces were then stuck transversely on the nail plate to counteract the overcurvature. Within 3-6 months the nail growth was normalized in two cases and almost completely normalized in the third.

Adult↗
PubMed1992

Linear arrangement of multiple congenital melanocytic nevi.

A 28-year-old man had numerous slightly papillomatous melanocytic nevi that were arranged in a linear pattern on his right arm. Their distribution was reminiscent of the lines of Blaschko. The nevi had been present since birth and were in part covered with terminal hair. Histopathologic examination showed typical features of congenital melanocytic compound nevi. In addition, the blue-eyed patient showed an iris bicolor in the form of a sectorial brown pigmentation of his right iris. This unusual case may provide a clue to the genetic basis of pigmented nevi.

Adult↗
PubMed1992

[Leukonychia longitudinalis as the primary symptom of Hailey-Hailey disease].

Longitudinal white bands on the fingernails were observed in a 58-year-old male patient with perianal intertrigo. His nail changes were a first clue to the diagnosis of Hailey-Hailey disease, which was later confirmed histopathologically. Similar nail abnormalities were found in the patient's son who was also affected with Hailey-Hailey disease. These findings support the concept that those nail changes, first described by Burge in 1991, constitute a useful diagnostic marker in Hailey-Hailey disease.

Biopsy↗
PubMed1989

[Noncompliance relevant variables in patients with onychomycosis].

In a prospective clinical study we have investigated the relevant non-compliance variables with 96 patients affected by onychomycosis, who underwent a combined treatment of nail abrasion and application of a topical antifungal. The patients' non-compliance amounted to 24% of the complete group examined. Significantly this occurred more frequently with men (31.6%) than with women (12.8%), and also more frequently with older women than younger women. It occurred with 42% of the male and female pensioners and with 43% of the students. Furthermore, the group of non-compliance patients, in addition to their onychomycosis, frequently exhibited other illnesses requiring treatment in greater degree than the compliant patients. Additional rising variables, e.g. in the seriousness of the clinical outbreaks on the nails and the number of mycotic nails, did not contribute to an explanation of the differences in compliance behavior of the patients. By careful observation of the compliance factors in relation to specific illnesses, a more favorable set of conditions should be achieved in future for the improvement of patient behavior.

Administration, Topical↗
PubMed1989

In vivo effects of terbinafine and ketoconazole on testosterone plasma levels in healthy males.

Ten healthy male volunteers received daily 200 mg of ketoconazole or 500 mg of terbinafine (SF 86-327) for a period of 8 days according to a crossover double-blind design. Between the periods of treatment there was an interval of 3 weeks. Before and during the treatments, on 3 days in all, blood levels of testosterone were determined in the morning at 08.00 and 12.00 h. On the following day in each case, after taking a basal blood sample, 5,000 IU of hCG were injected intravenously and 2 h later a further blood sample for plasma testosterone determination was taken (short-term hCG stimulation test). Prior to treatment, the mean plasma testosterone levels at 12.00 h were slightly below the level at 08.00 h (6.5 +/- 3.5 against 7.2 +/- 3.1 ng/ml). The difference increased and was statistically significant with ketoconazole treatment (4.2 +/- 3.2 against 7.7 +/- 3.0 ng/ml), but did not alter during administration of terbinafine (7.8 +/- 4.4 against 6.8 +/- 3.0 ng/ml). The administration of testosterone levels by hCG stimulated 25.6% prior to treatment. The stimulation was suppressed to zero by ketoconazole but clearly intensified (41.7%) by terbinafine treatment. The results demonstrate once more the well-known effect of ketoconazole on testosterone production and confirm that terbinafine obviously does not have this effect.

Adult↗
PubMed1987

[Cutaneous artefacts--possibilities for treatment and their limits].

Factitious disorders (FD) of the skin are emergency calls of the patient, whose psychological problems are mostly unconscious. The therapeutic approach is difficult, because the patient does not accept the necessary psychiatric or psychotherapeutic therapy. Therefore, they remain under the medical care of their dermatologists. We report on the experiences of our psychological team gathered during a clinical study on 16 patients with FD. We distinguish between three types of FD, each implicating a different therapeutic approach: unconscious FD (type A), conscious FD (type B), and so-called neurotic excoriations (type C). On the basis of 3 corresponding cases, we discuss the possible psychosomatic therapeutic approaches, the indications and limits of the treatment, as well as prognostic aspects.

Adult↗
PubMed1987

Environmental risk factors in the history of male patients of an infertility clinic.

93 consecutive patients attending our andrologic department for marital infertility were asked for possible environmental risk factors including traumata, heat, noise, smoking, radiation, micro waves, pesticides, and plastics. The data were correlated to the mean seminal parameters. No significant differences were found between patients being positive for a certain risk factor and those being negative.

Adult↗
PubMed1985

[Wound closure in the care of small skin defects].

We give a survey on the present situation regarding the methods and indications of punch biopsy as well as similar operations, including the design, orientation, and execution for the repair of small skin defects.

Biopsy↗
PubMed1985

[How does ketoconazole affect testosterone metabolism?].

Inhibition of the testosterone synthesis caused by ketoconazole was studied in healthy young men. They received the drug for seven days at a dose of 200 mg daily. Neither the blood level of total plasma testosterone nor that of the free fraction showed any alteration during treatment. 24 hours after treatment, however, the response of plasma testosterone to hCG was diminished. These findings indicate a delayed effect of ketoconazole on the synthesis of testosterone, although its blood levels are decreased to nearly zero. The effects of ketoconazole are due to its binding to enzymatic proteins. Thus the link to other proteins binding androgens might be possible. Our experiments demonstrated that ketoconazole may inhibit the binding of testosterone to antibodies in a RIA system as well that to SHBG.

Adult↗
PubMedDate not supplied

Epidermal cytokines in murine cutaneous irritant responses.

Investigations on cytokines in skin irritancy or non-immunological irritant contact dermatitis (ICD) should improve our understanding of their complex mechanism. Numerous studies showed, however, that similar epidermal cytokines have been detected in irritant and allergic reactions, suggesting a lack of specific cytokines that clearly differentiate allergic from irritant reactions even though the pathomechanisms between allergic contact dermatitis (ACD) and ICD are distinguished. Recent data, however, indicate that some mediators may be restricted to allergic responses (contact hypersensitivity). This could provide the impetus to study their implication on irritant reactions. We overview the epidermal cytokines involved in irritant responses compared to those in contact hypersensitivity based on published results of studies using in vitro cell-cultured murine keratinocytes and in vivo murine models.

Animals↗
PubMedDate not supplied

Characteristics of self-estimated enhanced skin susceptibility.

A considerable number of people complain about enhanced skin sensitivity. The aim of this study was to investigate the characteristics of subjective statements and objective measurable parameters in subjects with self-estimated enhanced skin susceptibility. Four-hundred-and-twenty volunteers completed a questionnaire form with a self-estimation of skin susceptibility, possible triggering factors and other skin problems. In addition, basal values of transepidermal water loss, cutaneous blood flow and skin hydration were measured. One-hundred and fifty-two volunteers were also patch-tested with sodium lauryl sulphate 0.5% on the forearm and evaluated by bioengineering methods. We found no correlation between self-estimated skin susceptibility and bioengineering values, neither basal nor after sodium lauryl sulphate testing. These findings, along with interpretation of the questionnaire form, suggest that self-estimated enhanced skin susceptibility is a subjective problem mostly reported by women and of all ages.

Dermatitis, Irritant↗