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Biomedical subjects

I Effendy

Publications and source records attributed to I Effendy.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Response to thermal stimuli in skin pretreated with sodium lauryl sulfate.

Skin irritation is mostly a multifactorial process. Competitive effects of different chemical irritants are well known. This study investigates the influence of a thermal stimulus on skin pre-irritated with sodium lauryl sulfate (SLS). Seventy-seven volunteers were patch-tested with SLS 0.25% and 0.5% for 48 h. Water served as control. Skin reaction was evaluated by measurement of transepidermal water loss, skin blood flow and skin color. After measurement, a thermal stimulus was applied on the test area. The increase in skin blood flow was measured. There was a significant correlation between the degree of irritation and the increase in skin blood flow after thermal stimulus. Pre-irritated skin reacted to thermal stimulus with a shorter and sharper increase in skin blood flow. This increase was dependent on the SLS concentration. Hence, the thermally stimulated blood flow may be a model of non-chemical irritation and seems to be a relevant co-factor in the pathogenesis of irritant dermatitis.

Adolescent↗
PubMedDate not supplied

Comparative efficacy and safety of bifonazole 1% cream and the corresponding base preparation in the treatment of seborrhoeic dermatitis.

Seborrhoeic dermatitis is a common entity that conventionally is difficult to treat. Recently, topical ketoconazole has been proven successful. To determine if other azoles, and in particular the more modern ones, are also helpful in this condition, a double-blind multicentre randomized controlled trial was performed in patients suffering from seborrhoeic dermatitis involving individuals 16 years and older without human immunodeficiency virus (HIV) infection. One hundred patients were enrolled and treated according to a random plan with either bifonazole 1% cream or the corresponding vehicle once daily for 4 weeks. All patients were evaluated at the beginning of the study, as well as after 2 and 4 weeks, i.e. the treatment period proper, and after 6 weeks of follow-up. Clinical evaluation was based on scores of 0-3 for the following parameters: erythema, papules, infiltration, scaling, itch. In addition, mycological evaluation was performed using adequate contact plates for quantitative determination of Malassezia furfur. In the end, 92 patients were at least partially evaluable. In general, the verum preparation tended to be more efficacious, e.g. the score for erythema amounted to 0.75 after 4 weeks as compared with 0.88 in the control group, the baseline values being 2.18 and 2.04 respectively. With itch, the corresponding figures were 0.17 and 0.33 as compared with 1.42 and 1.38 before treatment. While in statistical terms there was significant difference in these parameters, such a difference was demonstrated by clinical judgement at follow-up.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Topical↗
PubMedDate not supplied

Evaluation of skin susceptibility to irritancy by routine patch testing with sodium lauryl sulfate.

Irritant patch testing with sodium lauryl sulfate (SLS) will become more and more a routine test determining skin susceptibility in men. Recently, it has been shown that for practical reasons, irritant SLS patch testing can take place on the back simultaneously with a routine allergic patch test to other contact allergens. However, SLS patch testing has mostly been performed on the forearm in studying experimental skin irritation so far. The aim of this study was to determine whether there is a relationship in skin response to aqueous SLS (0.125%; 0.25%; 0.5% and 1.0%) between the forearm and the back assessed by visual scoring and measurement of transepidermal water loss (TEWL). We found a pronounced reaction of the forearm compared to the back. TEWL values as well as visual scores correlated well with SLS concentration. There was also a high correlation in visual scoring between the forearm and the back. Based on test sensitivity and specificity we suggest a 48 hrs patch test for routine screening with 0.5% SLS on the forearm evaluated by TEWL measurement or visual scoring 24 hrs after patch removal. A mild erythema (scored as < or =1) is considered to be normal. If for practical reasons, the SLS patch is placed on the back simultaneously with the allergic patch test, 0.5% SLS may be sufficient, too. TEWL measurement so far provides a reliable method and will certainly be necessary for experimental studies on irritant skin reactions, particularly when different SLS concentrations are used. After a 48 hrs patch test with SLS 0.5% TEWL measurement should be performed at 72 hrs. A value of < or =31.6 g/m(2)hr seems to follow the normal distribution.

Back↗
PubMedDate not supplied

Filamentous fungi and yeasts on mattresses covered with different encasings.

Besides mites, filamentous fungi and yeasts play an important role as domestic allergens. Among different allergen avoidance strategies the efficacy of synthetic mattress encasings has been demonstrated for the reduction of house dust mites. Whether these synthetic encasings are also able to reduce the growth of fungi on the mattress under domestic conditions has not been assessed so far. To determine if the fungal growth on mattresses can be reduced by the use of synthetic encasings we assessed the fungal colonisation of mattresses covered either by conventional cotton encasings or by polyurethane encasings impermeable to particles > 3 mum. Within a 12-month period dust samples were obtained from the mattresses. Fungal quantities were measured by counting colonies on agar plates incubated at 20 degrees C and 37 degrees C. The counts of fungi were significantly higher on mattresses with cotton encasings. Penicillium spp. and Aspergillus spp. were isolated most frequently. Therefore the application of synthetic encasings with similar properties to the encasings used in this investigation is recommended as part of an allergen avoidance strategy for patients sensitised to fungal allergens.

Adult↗
PubMedDate not supplied

Skin susceptibility to dithranol: contact allergy or irritation?

A pronounced skin reaction to rather low concentrations of dithranol is often observed. The question arises as to whether this represents an allergic or irritant reaction. We performed patch tests with dithranol ointment in various concentrations on psoriatic patients and healthy volunteers. The results failed to show any clear-cut difference in skin reactions between psoriatic patients and healthy volunteers. One subject with a previously known skin hyperreactivity to dithranol showed a similar response to those of some healthy probands. However, subjects showing a pronounced response to rather low concentrations of dithranol also demonstrated a strong reaction to sodium lauryl sulphate, a standard irritant. We conclude that increased reactivity to dithranol most likely reflects an increased genuine skin susceptibility, rather than an allergic response.

Administration, Topical↗