[Effect of ionizing radiation on the protein amino groups of erythrocyte membranes].
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Biomedical subjects
Publications and source records attributed to I G Akoev.
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White mongrel male mice with subcutaneously grafted Ehrlich adenocarcinoma were exposed at week intervals to three three-day sessions of low-intensity (5 microWt/cm2) super short wave-therapy from two generators of oscillating frequency in the range of 2-18 GHz. As a result of treatment, the increase in tumour size was diminished, and the probability of its reverse development was increased, with animal lethality being decreased. During a month the recovery was increased from 0 to 50% in the first experiment and from 38.3% to 60% in the second. In the third experiment, the recurrence during a 72-day observation period was showed in none of the recovered mice.
A clearly pronounced modification of acute radiation injury of mice has been obtained by prolonged action (for up to 23 hours) of low-intensity (5 +/- 1.5 mu Wt/cm2) radiofrequency radiation in the ranges of 2-8, 8-18 and 19-27 GHz with a swing frequency of 12-14 Hz, applied immediately after exposure to lethal dose of gamma-radiation. Survival of mice and average life duration of killed mice were increased.
Primary investigations have been carried out to determine whether low-intensity EMR of a cm range exerts the radioprotective effect. Prior to gamma-irradiation with doses LD100/30 and LD60/30 mice were exposed for 23 h to 2-8 GHz microwaves with a swing frequency of 12-14 Hz, at energy flow density of 5 +/- 1.5 mu Wt/cm2. Survival and time of death of mice were registered during a month. With absolutely lethal doses of gamma-irradiation, the application of SHF EMR delayed the time of animal death by 2.8-4.2 days and led in one of the experiments to 20% survival of mice. With doses in non-absolutely lethal range, the pretreatment of mice with EMR increased the survival by 20% in two experiments.
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Solution of rat muscle actomyosin (AM) was exposed to pulse-modulated microwave. Carried frequency was 2375 MHz. The rectangular pulse modulation was in the range of 50-300 pulses per second. It was shown that AM activity was dependent both on modulation frequency as well as on microwave intensity. It was shown the frequencies of modulation which were changed ATP-ase activity of AM.