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Biomedical subjects

I Halbrecht

Publications and source records attributed to I Halbrecht.

At least 73 records · Page 4Linked to original sources
PubMed1980

New complex Ph' translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia.

A patient with chronic myelocytic leukaemia (CML) and a new complex Philadelphia chromosome (Ph') translocation, t (10; 14; 22), is described. This three way Ph' translocation not involving chromosome 9 was present in the majority of the bone marrow cells, as well as in a great proportion of metaphases from phytohaemagglutinin (PHA) stimulated peripheral blood cultures. The possibility that the Ph' translocation was present also in lymphocytes is discussed and at this regard the involvement of chromosome 14 is of interest considering the documented non random involvement of chromosome 14 in lymphoid malignancies.

Aged↗
PubMed1980

Enzyme activities in regenerating liver of rats.

the activities of eight enzymes were determined in the regenerating liver of rats after partial hepatectomy. For five enzymes, i.e., aldolase, lactate dehydrogenase, alanine transaminase, 5-nucleotidase, and acid phosphatase a progressive statistically significant increase in activities was obtained on days 10 and 20 of regeneration. This increase was not at the high level observed for parallel activities in fetal liver of rats on the 20th day of gestation. A possible interpretation of the process of liver regeneration is suggested.

Animals↗
PubMed1980

Ultrastructural studies on the lymphocyte subpopulations of disaggregated mouse spleens.

The lymphocyte subpopulations of disaggregated spleens of adult C57Bl/6J mice were examined by transmission and scanning electron microscopy as well as by rosette formation. The results showed that most lymphocyte subpopulations are constituted of cells with relatively smooth surfaces. Rosette formation showed that the proportion of E rosettes, compatible with the presence of T cells, was of 25%, whereas that of erythrocyte antibody complement (EAC) rosettes, indicating B cells, was 9%.

Animals↗
PubMed1979

Prostaglandin E2 and cyclic AMP levels in human breast tumors.

Prostaglandin E2 (PGE2) and cyclic adenosine-3', 5'-monophosphate (cAMP) concentrations were measured in human benign and malignant breast tumors by radioimmunoassay. Two groups were found among the malignant tissues, one with high PGE2 (M = 65.89 pg/mg) and high cAMP (M = 0.704 pmole/mg) concentrations and one with low concentrations (M = 9.24 pg/mg and M = 0.299 pmole/mg, respectively). The low PGE2 levels in the malignant tumors did not differ significantly from the levels found in benign tumors (M = 8.06 pg/mg). cAMP levels were positively and highly correlated (r = +0.81) with PGE2 levels. No bone osteolysis could be discovered in any of the patients a few weeks after mastectomy operation, but PGE2 analysis of breast tumors may have prognostic value for the future.

Bone Neoplasms↗
PubMed1979

Pure trisomy 17p in 60% cells.

A patient with pure trisomy of the short arm of chromosome 17 in 60% of the examined cells is reported. She presented a variant chromosome 1 with partial pericentric inversion and increased centromeric heterochromatin in one chromosome 17. The cytogenetic findings are discussed. The clinical findings are compared to those found in other reported cases of partial trisomy 17 and a delineation of a pure trisomy 17p attempted.

Abnormalities, Multiple↗
PubMed1979

Repeated abortions and histocompatibility antigens. Can HLA antigen restricted gene dose effects influence the feto-maternal relationship?

It is suggested that the induction of cytotoxic reactions in the mother by allogeneic fetal cells is HLA antigen restricted and influenced, in certain haplotype combinations, by gene dose effects of specific HLA antigens (locus A and B), shared by the fetus and by the mother. The possibility that alloimmunization of maternal cells to fetal transplantation antigens may have beneficial or adverse effects on the fetal target cells dependent upon feto-maternal histocompatibility antigen interrelationship would provide a new approach for interpreting functional disturbances in certain cases of human pregnancy.

Abortion, Spontaneous↗
PubMed1979

A hypodiploid clone and its duplicate in acute lymphoblastic leukemia.

Examination of the bone marrow of a 63-year-old man who had acute lymphoblastic leukemia revealed a population of cells with 32 chromosomes and another population with 64 chromosomes, the karyotypical exact duplicate of the first clone. The karyotypic evolution was studied and the findings compared with those described in two similar cases previously reported. It is postulated that severe hypodiploidy is associated with reduced capability of cellular survival, promoting a strong tendency for duplication.

Bone Marrow↗
PubMed1979

Risk of malignancy and chromosomal polymorphism: a possible mechanism of association.

A significantly increased incidence of heterochromatic chromosomal variants, particularly of A1 and C9, has been found in a group of 120 patients with malignant or premalignant diseases. People presenting with such a kind of polymorphism usually have an increased chromosomal breakage rate. Genetically increased susceptibility to breaking agents may be the unifying concept explaining the increased incidence of heterochromatic variants found in couples with sterility or abortions, in karyotypically normal malformed or retarded children, and in patients suffering from different malignant or premalignant diseases. Chromosomal imbalance is probably the basis for initiation of malignancy whose development is influenced by many different factors.

Adolescent↗
PubMed1979

Triple mosaicism 45,XY,--18/46, XY/47,XY,+18.

A patient with symptoms clinically resembling Edwards's syndrome is presented. Cranial asymmetry, thoracic and lumbar hemivertebrae, and an additional rib were the unusual features. The cytogenetic studies revealed the coexistence of three separate cell lines with 45,XY,--18/46,XY/47,XY,+18 complement.

Chromosomes, Human, 16-18↗
PubMed1978

A new cytogenetic aspect of polycythemia vera.

The cytogenetic findings in a group of 15 polycythemic patients are reported. G and C banding techniques were used on bone marrow and peripheral blood preparations. Major chromosomal aberrations were found in four out of the 15 patients, an incidence similar to that found in other studies on polymorphism. The most interesting finding concerned the chromosomal polymorphism of the pair 19. A possible relation to the etiology of the disease is discussed.

Adult↗
PubMed1978

Cytogenetic observations in infertile men working with insecticidal compounds.

The negative influence of some insecticides on male fertility has been noted. We report our cytogenetic observations on a group of infertile insecticide workers. Increased chromosomal breakage was a constant finding and the Y chromosome was especially damaged. This may account for impaired spermatogenesis. Furthermore, the involvement of heterochromatic chromosomal variants both in the individual susceptibility to the chemically induced damage and in the reproductive fitness is emphasized.

Antispermatogenic Agents↗
PubMed1978

The effect of sera from chronic lymphocytic leukemia patients on normal mitogen-stimulated lymphocytes. A possible correlation with the patients' T and B lymphocytes.

Serum from chronic lymphocytic leukemia (CLL) patients was examined for its effect on normal lymphocytes stimulated by phytohemagglutinin and pokeweed. Responses of the patients' lymphocytes were similarly examined. E and EAC rosettes were also tested. A significantly increased transformation response was found when normal lymphocytes were exposed to sera from those patients who had a reduced number of E-rosette-forming lymphocytes (mean 8%) as compared to the response to sera from patients with a higher number of E-rosette-forming cells. The results suggest that a factor is present in sera from some CLL patients which stimulates the transformation of mitogen-stimulated lymphocytes and which seems to be related to the number of the patient's T and B lymphocytes and perhaps with a T suppressor effect on B lymphocytes.

Aged↗
PubMed1977

Primary amenorrhea with a new mosaic 46,XXqi/47,XXqi Xp-. Consideration on the X isochromosome formation and X chromosome inactivation.

A case of Turner's syndrome was found to be 46,XXqi/47XX,qi Xp-, a new mosaic. The origin of such a mosaic, the formation of the Xq isochromosome using the C-banding technique, and the X chromosome inactivation are discussed. The Xq isochromosome was apparently monocentric, but probably with two strictly close centromeres. The inactivated X seemed to be the Xqi or the normal X alternatively.

Adult↗