PubMed Health⌕ Search

Biomedical subjects

I Halbrecht

Publications and source records attributed to I Halbrecht.

At least 91 records · Page 5Linked to original sources
PubMed1977

Lymphocyte reactivity in the aged.

Lymphocyte reactivity in cultures toward the nonspecific T and B cell mitogens, phytohemagglutinin (PHA) and pokeweed (PWM), was studied in 46 subjects in three groups: a) young healthy persons, b) elderly healthy persons, and c) hospitalized elderly patients with atherosclerotic cardiovascular disease. No statistically significant differences in the lymphocyte reactivity of young and old healthy persons toward PHA could be observed with different incubation times, mitogen concentrations, or serum sources. A significantly decreased lymphocyte response was found in elderly hospitalized patients compared to young and elderly healthy subjects. In contrast, no differences in the lymphocyte reactivity toward PWM could be found among the three groups, including a comparison between elderly healthy and elderly hospitalized persons. The results suggest that the B lymphocyte-dependent response to a B lymphocyte stimulator is more stable than is the T cell response in aged subjects.

Adolescent↗
PubMed1977

Ph1-positive acute lymphocytic leukemia with chromosome 7 abnormalities.

A 56-yr-old woman with acute lymphocytic leukemia showed the presence of a Philadelphia chromosome in 90% of the bone marrow metaphases and in 10% of the peripheral blood metaphases. Part of the long arm of a G22 chromsome was translocated to the long arm of a C9 chromosome. A second cytogenetic abnormality was found in chromosome 7. Monosomy 7 was found in 60% of the marrow and in 20% of the peripheral blood metaphases. Chromosome 7q- was also found in a small percentage of the metaphases examined. Three months later, when the patient was in partial remission, only 10% of the marrow cells showed chromosome 7 monosomy and a Ph1 chromosome. During complete remission, no chromosomal abnormalities were found, except for a high breakage rate. The finding of a Ph1 chromosome in acute lymphocytic leukemia indicates that different precursors, both granulocytic and lymphocytic, may be involved in the Ph1 process.

Cell Transformation, Neoplastic↗
PubMed1977

Sex-linked values of E-rosette forming lymphocytes in mother and newborn.

The T-cell marker of spontaneous rosettes with sheep erythrocytes was determined in 34 normal term-deliveries on the peripheral lymphocytes of the mother and the corresponding cord-blood lymphocytes of the newborn, immediately after delivery. A consistently lower level of E-rosette forming lymphocytes was observed in male as compared to female newborns in different parity groups and in twin deliveries. When the mean values were calculated for corresponding E-rosettes of maternal and newborn lymphocytes in each group (female and male group of offsprings) they were nearly identical.

Erythrocytes↗
PubMed1976

Human chromosome polymorphism and congenital malformations.

Several authors have suggested that heterochromatin polymorphism influences the origin and/or development of different malformations. In this investigation special consideration was given to the A1qh + variant. Several families with this variant are reported in which the incidence of otherwise rare malformations is surprisingly high. The possibility that the A1qh+ varient or, more probably, interactions between all types of heterochromatin polymorphism are of pathogenetic significance is considered.

Abnormalities, Multiple↗
PubMed1976

Aplastic anemia followed by leukemia in congenital trisomy 8 mosaicism. Ultrastructural studies of polymorphonuclear cells in peripheral blood.

The case of a 40-year-old patient with congenital trisomy 8 and sex chromosome mosaicism is discussed. The main clinical features were: mental retardation, thick and darkly pigmented skin, prominent forehead, convergent strabismus, high arched palate, flexion contractures of the extremities, and numerous skeletal abnormalities. The patient developed severe aplastic anemia followed by an interim period of preleukemia which developed into acute leukemia. Electron microscope examination of the white blood cells at the stage of the aplastic anemia showed ultrastructural abnormalities similar to those observed in other genetic disorders with a predisposition to leukemia, as well as in leukemia.

Acute Disease↗
PubMed1976

Cellular and humoral immune aspects in mixed wife-husband leukocyte cultures in spontaneous abortions.

The possible role of feto--maternal cell--and humoral mediated immunological reactions, in mixed wife-husband one- and two-way stimulated leukocyte cultures (MWHLC) in autologous serum were investigated in a comparative study of 27 cases of normal and abnormal pregnancies (8 control and 19 cases of spontaneous abortions). Sera obtained from women after spontaneous abortions had a significantly higher stimulating effect on MWHLC than sera from women with normal pregnancies. In one-way stimulated MWHLC in cases of abortions, this effect was evident on maternal responding cells incubated with mitomycin treated paternal leukocytes.

Abortion, Spontaneous↗
PubMed1976

[Induction of second trimester abortion by infusion of intraamniotic hypertonic and extraamniotic physiological saline solution (author's transl)].

In a group of 84 women in the second trimester of pregnancy abortion was induced by intramniotic transabdominal instillation of 20 per cent NaCl. In a second group of 91 women the abortion was induced by means of extraamniotic physiological infusion of saline solution. The only complication observed in the first group was an increasing fever. In the second group there were better results. The fetus abortion was complete and in a shorter time. We assume that the new method is the method of choice because it gives no complications and may be easily performed. It may be used also in cases of missed abortion or intrauterine fetal death.

Abortion, Induced↗
PubMed1975

Mid-trimester abortion with intra-amniotic prostaglandin F2 alpha and intravenous oxytocin infusion.

Induction of abortion in mid-trimester pregnancies were performed on 26 patients. The first 12 patients were treated by intra-amniotic instillation of Prostaglandin F2 alpha, with a mean dosage of 40.2 mg. and mean abortion time of 24 hours and 41 minutes (ten patients). Fourteen additional mid-trimester abortions were performed using identical protocol plus the addition of oxytocin by intravenous infusion two hours after injection of the prostaglandin. All patients aborted, with mean dosage of PGF2 alpha of 28.2 mg. and mean abortion time of 15 hours and 37 minutes.

Abortion, Induced↗
PubMed1975

An unusual case of hemoglobin Bart's hydrops fetalis.

A baby with alpha-chain thalassemia hydrops fetalis was born to an Iraqian Jewish couple of Iraqi-Kurdish extraction. Hemoglobin Bart's constituted only 40% of the total hemoglobin, much less than usually found in alpha-thalassemia hydrops fetalis. That this is a particular expression of hemoglobin H disease is considered. The likelihood of two alpha-chain loci, rather than one alpha-chain locus, in this family, is also discussed.

Edema↗
PubMed1975

Ultrastructural study of the erythropoietic events in human embryonic livers.

The ultrastructural features of the erythropoietic events in 5- to 9-week embryonic livers are described. By the 5th week of gestation, the human embryonic liver becomes an active site of erythropoiesis represented by the formation of reticular-mesenchyme cells and hemocytoblasts. At the 6--7th week, the first proerythroblasts and islands of polychromatophilic and orthochromatic erythroblasts can be detected. From this stage, by the 8th week of embryonic development, the liver assumes its function as a fully developed embryonic organ. In the embryonic livers studied there were no signs of granuloor lymphopoiesis. Although megakaryocytes were found in the 8-week embryonic liver, there is no evidence that these cells are produced in the liver. Macrophages were found in the 5-week embryonic liver.

Embryo, Mammalian↗