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Biomedical subjects

I Horowitz

Publications and source records attributed to I Horowitz.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Sulfasalazine in rheumatoid arthritis].

Sulfasalazine (SLZ) is now a second-line treatment in rheumatoid arthritis (RA), as well as in psoriatic arthritis and ankylosing spondylitis. 54 patients with active RA were treated with enteric coated SLZ (2 g daily) in a 24-week open study. Clinical and laboratory parameters of disease activity were monitored initially and thereafter at 2-week intervals for the first 2 months, and then at 4-week intervals until the end of the 24-week study. There was significant clinical improvement at the end, as shown by scores for joint pain (Ritchie), grip strength and morning stiffness (p less than 0.0001, less than 0.0001 and less than 0.01, respectively, by paired t test). Clinical improvement was accompanied by significant decrease in erythrocyte sedimentation rate and increase in hemoglobin (p less than 0.002 and less than 0.016, respectively). There was improvement in some cases as early as 3 weeks after starting therapy. The drop-out rate was significant: 19/54 (35%), most (13) due to side-effects, mainly gastrointestinal; none of the side-effects were serious. Our results, similar to those of other studies, indicate that despite the high rate of side effects, SLZ is an effective, second-line drug for RA.

Arthritis, Rheumatoid↗
PubMed1991

Treating the latrogenically infantilized patient.

The treatment of an "iatrogenically infantilized" patient by cotherapists using a dialectical approach is described. By focusing on the adult part of the patient, the here and now and on behavioral change rather than on the past, catharsis and insight, the development of dependency and regression were discouraged, while growth and independence were encouraged. The practice of providing further treatment to patients with poor responses to past psychotherapeutic aid is questioned and an alternate approach is suggested.

Adolescent↗
PubMed1990

Clonidine dosage.

Explore the source record for details and available documents.

Clonidine↗
PubMed1989

Direct coronal high resolution computed tomography of the temporomandibular joints in patients with rheumatoid arthritis.

Direct coronal high resolution computed tomography (CT) examination of the temporomandibular joints (TMJ) was performed in 40 patients with rheumatoid arthritis (RA). The patients were divided into 3 groups. Group 1 included patients with juvenile rheumatoid arthritis (JRA). Four patients of this group had disability of the TMJ associated with overgrowth of one of the mandibular condyles. This phenomenon has not yet been reported. Group 2 consisted of 10 patients with RA with clinically asymptomatic TMJ, 4 of whom had mild erosions of the condylar head seen on CT, consistent with RA. The majority of patients in Group 3, with clinically symptomatic TMJ showed CT changes of various degrees, which are discussed in this paper. Mild bone changes, not demonstrated by conventional procedures, were clearly seen by CT. Coronal view of the CT examination had advantages over other projections.

Adolescent↗
PubMed1988

Late neuropsychologic status after childhood head trauma.

A neurologic and neuropsychologic test battery was administered to a sample of 35 children drawn from all those in a defined geographic area who had been hospitalized for head trauma before age 7 during the years 1970-1976. Examination was performed 3 1/2 to 10 years after injury, at age 6-15. Twelve subjects had been diagnosed at the time of injury as suffering moderate insult and had been referred to the metropolitan neurosurgical center, while twenty-three with only mild injury had been retained for observation in a local pediatric ward. The twelve with more severe insult were significantly inferior to the other subjects on the Block Design and Coding subtests of the revised Wechsler Intelligence Scale for Children. The Koppitz score of the Bender Test, the WISC-R scatter, the Benton Visual Retention Test, the GATB Motor Speed Test and the Bourdon-Wiersma Vigilance Test showed less diagnostic power and failed to distinguish between the group with more severe injury and that with less. A detailed and carefully scored neurologic examination also failed to distinguish between the two groups. The findings suggest that relatively common traumatic injury may be associated with detectable late cognitive deficit, and that some WISC-R subtests may be among the best measures for detecting such deficit.

Brain Injuries↗
PubMed1987

Recurrent aphthous stomatitis of the Behçet's type: successful treatment with thalidomide.

A 48-year-old man with a 27-year history of debilitating recurrent aphthous stomatitis major and pustular skin lesions was treated successfully with thalidomide. Side effects have not been encountered during a 6-month symptom-free period, while he has taken 25 mg per day. The drug is currently unavailable in this country except for the treatment of leprosy. It is hoped that publication of the dramatic response to thalidomide in this one instance will encourage greater interest in this potentially useful drug.

Behcet Syndrome↗
PubMed1987

Dentinogenic ghost cell tumor.

A case of peripheral calcifying odontogenic cyst is presented. The nature of the lesion as a neoplasm is discussed including review of the literature. The terminology proposed for this lesion is "dentinogenic ghost cell tumor."

Adult↗
PubMed1987

The simple central odontogenic fibroma. A case report.

A rare case of central odontogenic fibroma - a simple type according to Gardner's classification - is presented. Clinical manifestations and treatment are described. The aetiology and histopathological differential diagnosis are discussed.

Adult↗
PubMed1987

Peripheral ameloblastoma--a clinical dilemma in gingival lesions.

A case of peripheral ameloblastoma on the gingiva of a 50-year-old male is presented. The clinical and histological picture of the lesion is described. The etiology and the dilemma in the differential diagnosis of this peripheral odontogenic tumor is discussed.

Ameloblastoma↗
PubMed1987

Bronchial response to methacholine in parents of asthmatic children.

Cumulative dose response curves to inhaled methacholine were established in 28 parents of asthmatic children, seven parents of healthy children, and four asthmatic patients. Bronchial sensitivity was defined as the dose of methacholine causing a 25 percent decrease in specific airway conductance while bronchial reactivity was determined by the slope of the cumulative dose response curve. Results indicated that parents with allergic rhinitis or airflow limitation in small airways may represent a high risk group, while parents with no atopy and normal pulmonary functions may reflect only the inherited characteristics of bronchial response.

Adolescent↗
PubMed1986

Accidental displacement of impacted maxillary third molars.

3 cases of accidental displacement of maxillary impacted 3rd molars are presented. 2 were displaced into the maxillary sinus and 1 into the infratemporal fossa. The difficulties in locating these displaced teeth are described and demonstrated on a dry skull model. The mode of treatment is discussed.

Adult↗
PubMed1986

Magnetic resonance imaging of the temporo-mandibular joint and meniscus dislocation.

A preliminary study of the temporo-mandibular joint (TMJ) by magnetic resonance imaging (MRI) was performed. Ten asymptomatic volunteers with no clinical history of TMJ disorder and five patients with a recent history of trauma to the TMJ were examined using a special surface coil. The meniscus, which is only slightly brighter than the surrounding tissue, gave a high signal and was demonstrated very clearly in its normal position in the controls and shown to be dislocated in the post-trauma cases. Four criteria for identification of the temporo-mandibular meniscus were established in the normal cases and compared with the findings in the pathological cases.

Adolescent↗