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Biomedical subjects

I Horowitz

Publications and source records attributed to I Horowitz.

At least 55 records · Page 3Linked to original sources
PubMed1984

Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate.

A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental production of gastric adenocarcinoma. The authors were able to produce adenocarcinomas in rats, but found a great number of gastric leiomyosarcomas. These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group.

Adenocarcinoma↗
PubMed1983

Childhood head injuries in Israel: epidemiology and outcome.

Results are reported of a regional survey of hospitalized head injuries in Israeli children aged 0-7 years during the period 1970-1976. There were 370 such cases surveyed. Incidence of head injury requiring hospitalization was 1.71/1000 per year. Follow-up examination 4-10 years after injury was achieved in 50 per cent of the cases. Late seizures and focal neurological deficit were rare, while school failure and various neuropsychiatric symptoms were common. Prevalence of seizures and new nervous habits was significantly related to severity of injury, while the prevalence of fears, nightmares, dizziness and school failure was not.

Achievement↗
PubMed1979

Melanotic neuroectodermal tumor of infancy (pigmented melanoameloblastoma).

The paper describes a large pigmented maxillary tumor in a 46-day-old infant. The histological examination showed the tumor to be a melanotic neuroectodermal tumor of infancy (MNTI). No raised urinary levels of vanilmandelic acid could be shown. The tumor was surgically removed and during a 5 1/2-year follow-up period there was no clinical evidence of recurrence. The origin, behavior and treatment of these rare tumors are discussed.

Female↗
PubMed1979

Lung cancer mortality in aluminum reduction plant workers.

The lung cancer mortaltiy of 5406 men (cohort 1) employed at one aluminum smelter on January 1, 1950, and of 485 men employed at a second plant (cohort 2) on January 1, 1951, is reported. For each man, the total number of years of exposure to tars, number of years since first exposure to tars and an index of exposure to tars expressed in tar-years were calculated. More than 99% of the men in the first cohort and just less than 98% of the men in the second cohort were traced. As of December 31, 1973, 1070 men in cohort 1 had died and death certificates were obtained for 990 men (92.5%). As of December 31, 1973, 64 men in cohort 2 had died and death certificates were obtained for 58 (91%). There were 84 deaths from lung cancer in cohort 1 and 11 in cohort 2. The results showed that the mortality from lung cancer of that portion of the cohorts 1 and 2 combined who had ever been exposed to tars was similar to that of workers never exposed to tars. The mortality from lung cancer of men in cohort 1 was greater than that expected at Quebec provincial rates, but this was probably due to slightly increased lung cancer mortality in the communities serving the industries. Although the total number of cases in cohort 2 was small tuld not be explained on community experience. There was a definite dose-response relationship between lung cancer mortality and tar-years and years of exposure. The standardized mortality ratio for persons exposed for more than 21 years to the higher levels of tars was 2.3 times that of persons not exposed to tars. Although smoking may still be a factor, the evidence suggests that the increased risk of lung cancer is related to employment in definite tar-exposed occupations.

Adolescent↗
PubMed1978

Effect of N-methyl-N'-nitro-N-nitrosoguanidine on the gastric mucosal barrier in rats.

The gastric mucosal barrier to hydrogen ion (H+) after the administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the rat stomach was studied. Increased H+ back-diffusion was observed 3 hr after oral doses of 1 mg of MNNG over a 3-day period. MNNG in concentrations of 250 microgram/ml, 167 microgram/ml, 86 microgram/ml, and 50 microgram/ml in the presence of acid caused increased H+ back-diffusion across the gastric mucosa within 1 hr. Gastric mucosal barrier disruption by MNNG may play a pathogenic role in gastric carcinogenesis.

Animals↗
PubMed1978

A large mandibular tumor with a distinct radiological "sun-ray effect" as the primary manifestation of multiple myeloma.

The significant feature of the reported case was that of a sinister-looking mandibular tumor highly suggestive of a metastatic lesion or of osteogenic sarcoma. A biopsy specimen and results of a thorough medical work-up showed the lesion to be multiple myeloma. The myeloma cells apparently have the capability to stimulate osteoblastic activity and new bone formation. This capability should be kept in mind when making the differential diagnosis of osteoblastic bony lesions of the jaws.

Aged↗
PubMed1977

Osteochondroma of the coronoid process of the mandible.

A case of osteochondroma of the coronoid process is presented. The proper diagnosis of ill-defined symptoms in the temporomandibular joint requires conformity between clinical manifestations and radiologic findings. The importance of a thorough radiologic examination is stressed for the correct diagnosis of these rare, insidious, slow-growing tumors. A short review of the literature is presented, and the treatment and surgical approach to these tumors are discussed.

Chondroma↗
PubMed1977

Pericardial tumor of fibrosis mimicking pericardial effusion by echocardiography.

Echocardiograms of three patients with metastatic carcinoma or lymphoma showed a sonolucent space posterior to the left ventricular epicardium, as seen in pericardial effusion. However, at surgery or autopsy no pericardial fluid was found. Instead, the pericardium was infiltrated by neoplastic tissue or fibrosis. In view of this finding, we suggest caution in the interpretation of "positive" echocardiograms for pericardial effusion in patients with neoplastic disease, especially if pericardiocentesis is being considered.

Adenocarcinoma↗
PubMed1977

Fat embolism syndrome in delirium tremens.

Delirium tremens in a common feature in the alcoholic population. The Fat Embolism Syndrome (FES) is characterized by fever, encephalopathy, respiratory failure and skin petechiae. Fat embolism has been associated with alcoholics but the diagnosis was apparent only at autopsy. We present an alcoholic male who developed delirium tremens unresponsive to therapy, followed by features of the FES. Asterixis and Korsakoff's psychosis are newly described features of this syndrome. Corticosteroids were a definitive therapy in this case.

Alcohol Amnestic Disorder↗