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I I Gorpinchenko

Publications and source records attributed to I I Gorpinchenko.

40 records · Page 3Linked to original sources
PubMedDate not supplied

[An analysis of the mutations in the gene of the mucoviscidosis transmembrane regulator protein (MTRP) in patients with congenital bilateral aplasia of the vas deferens].

The genetic background of congenital bilateral aplasia of vas deferens (CBAVD) was studied. Eight patients from Ukraine were enrolled in our study. In each case, the clinical diagnosis of CBAVD was confirmed by testicular biopsy. None of patients had other clinical features of CF except high level of sweet Cl. Individuals underwent genetic screening for mutations in CFTR gene. Genomic DNA from six individuals was analysed for the 9 mutations and from two patients for the 20 most common CF mutations in European population. In 3 patients, the mutation identified was delF508 and in 3 patients was found to have the R117H mutation (in all cases one mutation per individual only). Our results confirmed hypothesis that isolated CBAVD is incomplete (genital) form of cystic fibrosis.

Adult↗
PubMedDate not supplied

[Chlamydial infection in patients with inflammatory diseases of the genitalia].

Examination of patients with inflammatory diseases of the genital organs showed high percentage of Chlamydia infection in male localized diseases accounting for 42.8%, 48.0%, and 57.1% in urethritis, urethroprostatitis, and infertility respectively. In a major proportion of cases (73.0%) Chlamydia infection occurred in association with different kinds of microorganisms (bacteria, protozoans, fungi of Candida genus, etc.) chlamydiae are considered to be the leading etiologic factor of the female genitalia inflammatory diseases accounting for 32.4 to 51.0% depending on the method of examination employed. The most effective treatment option was found to be that of combination of realdiron with sumamed.

Adolescent↗