Dissociation of somatostatin effects. Peptides inhibiting the release of growth hormone but not glucagon or insulin in rats.
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Animals↗
Biomedical subjects
I Jaunakais
Publications and source records attributed to I Jaunakais.
Structure activity studies on somatostatin.
Seven synthetic analogues of somatostatin helped clarify structural requirements for suppression of growth hormone secretion in rats. Size of the ring is not critical; deletions of serine-13, lysine-4 or asparagine-5 result in peptides which retain an appreciable fraction of the activity. The analogue des-Ala1, Gly2, Asn5-somatostatin lowers plasma growth hormone and insulin levels without affecting plasma glucagon levels significantly.
Amino Acid Sequence↗
The influence of oral contraceptive steroids on serum lipids.
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Adult↗
Radioimmunoassay for serum myoglobin.
A column flow-through radioimmune assay for serum myoglobin has been developed. The assay uses antibodies to human or rhesus monkey myoglobin coupled to Sepharose by cyanogen bromide activation and myoglobin labeled by the Chloramine-T method. The labeled myoglobin is stable over two to three half-lives. Serum myoglobin levels were elevated when serum was taken up to 12 hours after myocardial infarction and generally elevated up to 24 hours. A continued or repeated elevation of serum myoglobin probably indicates continued myocardial damage or new attacks. In the cases of myocardial infarction, levels up to 1340 ng per ml were found.
Animals↗