Structure activity studies on somatostatin.

D Sarantakis; W A McKinley; I Jaunakais; D Clark; N H Grant

doi:10.1111/j.1365-2265.1976.tb03835.x

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Structure activity studies on somatostatin.

D Sarantakis·W A McKinley·I Jaunakais·D Clark·N H Grant

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Abstract

Seven synthetic analogues of somatostatin helped clarify structural requirements for suppression of growth hormone secretion in rats. Size of the ring is not critical; deletions of serine-13, lysine-4 or asparagine-5 result in peptides which retain an appreciable fraction of the activity. The analogue des-Ala1, Gly2, Asn5-somatostatin lowers plasma growth hormone and insulin levels without affecting plasma glucagon levels significantly.

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Amino Acid Sequence Animals Glucagon Growth Hormone Insulin Methods Rats Somatostatin Structure-Activity Relationship Journal Article

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D Sarantakis, W A McKinley, I Jaunakais, D Clark, N H Grant. 1976. Structure activity studies on somatostatin.. https://doi.org/10.1111/j.1365-2265.1976.tb03835.x

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