Biomedical subjects

I Milonas

Publications and source records attributed to I Milonas.

22 records · Page 2Linked to original sources

PubMedDate not supplied

Focal experimental epilepsy in rabbits.

The present study aimed at producing a chronic model of focal epilepsy in rabbits. In group A (30 rabbits) 0.05 ml alumina gel was injected in the right sensorimotor cortex, while in group B (10 rabbits) normal saline was injected in the same region. The observation period lasted 70 days. All group A animals developed spontaneous focal or focal initiated seizures that continued throughout the study. The rate of seizures varied in different animals. Both interictal and ictal epileptiform activities were recorded in the ECoGs. Histological examination showed a typical alumina granuloma with gliotic reaction adjacent to the granuloma.

Aluminum Hydroxide↗

PubMedDate not supplied

Carotid compression test and supraorbital photoelectric plethysmography in patients with carotid TIAs.

Fifty-two patients with carotid transient ischemic attacks (TIAs) were subjected to subsequent compression of the common carotid and superficial temporal artery. An EEG recording was monitored simultaneously with plethysmograms from both supraorbital regions during the arterial compression period. All patients were angiographically classified as normal (Group A, n = 25) with less than 50% stenosis (Group B, n = 14) and with more than 50% stenosis (Group C, n = 13), according to the degree of internal carotid stenosis. The carotid compression test was positive in 6 (11%) of our 52 patients, corresponding to 1 (4%) patient from Group A, 1 (7%) from Group B and 4 (30%) from Group C. In contrast, supraorbital photoelectric plethysmography (SOPPL) yielded abnormal results in 17 (33%) of our 52 patients, corresponding to 3 (12%) patients from Group A, 4 (28%) from Group B and 10 (77%) from Group C. We conclude that in view of the false positive results (12%) obtained with the SOPPL technique, the clinician who interprets these findings should be careful and combine these tests with other tests, preferably hemodynamic, for a final decision about the patient's status.

Adult↗

PubMedDate not supplied

Bilateral thalamic infarcts presenting as acute pseudobulbar palsy.

A 28-year-old, previously healthy, normotensive woman suddenly developed an acute pseudobulbar palsy with dysarthria, dysphagia, hypernasal voice and mild right arm paresis. Extensive laboratory investigations excluded all other possible causes of acute pseudobulbar palsy (neoplastic, inflammatory, demyelinative, myasthenic) and an MRI study demonstrated bilateral isolated thalamic infarcts. Oral contraceptives and smoking were the only possible stroke risk factors found and cerebral diaschisis the most tenuous explanation proposed. To our knowledge, this is the first report indicating that bilateral thalamic infarction on specific nuclei could be manifested as acute pseudobulbar palsy.

Adult↗

PubMedDate not supplied

Delayed diagnosis of spinal vascular malformations presenting as intermittent myelopathy.

We report our recent experience of three male patients, whose clinical diagnosis and subsequent surgery was delayed for 9.25 and 15 months respectively. Initially, they all presented with vague, either sensory or motor lower limb disturbances and intermittency of symptoms was followed by bladder dysfunction or impotence. Extensive laboratory work-up was unrevealing and the non-specific diagnosis of myelopathy further delayed the recognition of the underlying vascular lesion. Finally spinal magnetic resonance imaging (MRI), supine myelography and selective spinal arteriography indicated the presence of a tumor in the first patient and vascular malformation in the other two. Neurosurgery and histology confirmed one cavernous angioma and two arteriovenous malformations, all thoracic and dural. We believe that both the cryptic nature of these lesions and our technical limitations (spinal arteriography and MRI not readily available), accounted for the delayed diagnosis in our three patients, who nevertheless, when treated by surgery showed a satisfactory outcome in the first case, while further deterioration was prevented in the other two.

Adult↗