Focal experimental epilepsy in rabbits.

S Bostantjopoulou; Z Katsarou; I Milonas; N Taskos; J Logothetis

PubMed · 2121625

Focal experimental epilepsy in rabbits.

S Bostantjopoulou·Z Katsarou·I Milonas·N Taskos·J Logothetis

Abstract

The present study aimed at producing a chronic model of focal epilepsy in rabbits. In group A (30 rabbits) 0.05 ml alumina gel was injected in the right sensorimotor cortex, while in group B (10 rabbits) normal saline was injected in the same region. The observation period lasted 70 days. All group A animals developed spontaneous focal or focal initiated seizures that continued throughout the study. The rate of seizures varied in different animals. Both interictal and ictal epileptiform activities were recorded in the ECoGs. Histological examination showed a typical alumina granuloma with gliotic reaction adjacent to the granuloma.

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Aluminum Hydroxide Animals Cerebral Cortex Electroencephalography Epilepsies, Partial Evoked Potentials Nerve Degeneration Neurons Rabbits Seizures Stereotaxic Techniques Journal Article

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S Bostantjopoulou, Z Katsarou, I Milonas, N Taskos, J Logothetis. Focal experimental epilepsy in rabbits.. https://pubmed.ncbi.nlm.nih.gov/2121625/

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