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Biomedical subjects

I P Serova

Publications and source records attributed to I P Serova.

4 recordsLinked to original sources
PubMed1989

[Study of the process of inactivating oleandomycin phosphate preparations].

Ageing of oleandomycin preparations was studied. Certain biologically inactive components accumulating on storage of the preparations were isolated and investigated. A scheme for ageing of oleandomycin phosphate preparations is described. The scheme includes cleaving up of the water molecule at C11 and cleaving by the epoxide ring at the early stages and hydrolysis by the glycoside bonds at the later stages.

Chemical Phenomena↗
PubMed1982

[Isolation and study of the compounds of a peptide nature contained in an oleandomycin preparation].

Marketed oleandomycin phosphate, as well as the International Standard of oleandomycin (Great Britain, the 1st Int. Std., 1964) were studied with a purpose of determining their composition. The components were separated by liquid chromatography on columns with Sefadex LH-20 using 50 per cent ethanol as an eluent. The Lowry method using the biuret test and assays of the amino acids in the hydrolysates were used to show for the first time that marketed oleandomycin and its International Standard contained an admixture of the peptide nature. The data of the amino acid assays suggest that the admixture and oleandomycin is a fixed complex (adduct).

Amino Acids↗
PubMed1982

[Thermostability of inosine and its 8-substituted derivatives].

The derivatographic investigation of high temperature of inosine and its 8-substituted derivatives showed that the process of destruction involved 2 stages: low temperature endothermic decomposition at 120-220 degrees C without liberation of gaseous products (stage I) and high temperature exothermic decomposition to form water (stage II). The presence of electronegative 8-substituents in the inosine molecule made easier the cleavage of the N-glycoside link. This allows the conclusion that the reaction involved formation of intermediate ionic compounds based on ribose and hypoxanthine.

Chromatography, Thin Layer↗