Adult Wistar rats of both sexes were treated with Cyclophosphamide (a Romanian product), for 12 month. The Cyclophosphamide was given in the food, in 3 different doses (0.31, 1.25, respectively 2.5 mg/kg body weight). The modifications produced in the thymus and blood plasma were dose and sex dependent, and they emphasize an alteration in the protein metabolism, which is not accompanied by an involuntion of the thymus itself.

Amines↗

PubMedDate not supplied

The effects of hydrocortisone-acetate on some biochemical parameters in the liver, thymus, thymocytes and adrenals of white Wistar rats.

The administration of hydrocortisone-acetate to adult Wistar rats induced emphasized biochemical modifications in the thymus, together with the weight decrease of the gland. Liver was less affected and adrenal's function was suppressed, as shown by the increase of the ascorbic acid content. The treatment did not induce a stress situation.

Adrenal Glands↗

PubMedDate not supplied

Effects of leucotrofina and timolimfotropina on the liver of Wistar rats.

Adult male rats were treated for 10 days with a thymic extract (Leucotrofina-L, or Timolimfotropina-T, Ellem Milano, Italy), in a daily dose of 0.1 ml/100g body weight. 5 days after the end of the treatment, rats were sacrificed and liver was removed. The modifications in the liver were of the same direction for noth thymic extracts (an increase of the total protein content and of DNA concentration and a decrease of RNA concentration).

Adjuvants, Immunologic↗

PubMedDate not supplied

The electroencephalogram in third-age mental patients.

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Age Factors↗

PubMedDate not supplied

Comparative studies concerning the effects of hydrocortisone and of some synthetic glucocorticoids upon the thymocytes of the Wistar rats.

Thymocytes (isolated from the thymus of Wistar rats) were put in contact with the glucocorticoid hormones (hydrocortisone acetat, prednison, respectively superprednol) in the Warburg cup. The in vitro effects upon the biochemical parameters: total proteins, gammaglobulines, RNA, DNA, glucose and free nitrogen aminoacids, are more emphasized for both synthetic hormones than hydrocortisone, establishing a decreases in their levels.

Animals↗

PubMedDate not supplied

A multidisciplinary approach of the psycho-somatic involution syndrome.

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Aged↗