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Biomedical subjects

I Stoilova

Publications and source records attributed to I Stoilova.

14 recordsLinked to original sources
PubMed2004

Influence of local geomagnetic storms on arterial blood pressure.

This study attempts to assess the influence of local geomagnetic storms at middle latitudes on some human physiological parameters. The blood pressure (bp), heart rate and general well-being of 86 volunteers were measured, the latter by means of a standardised questionnaire, on work days in autumn, 2001 (1 Oct to 9 Nov), and in spring, 2002 (8 April to 28 May). These timespans were chosen as periods of maximal expected geomagnetic activity (GMA). Altogether, 2799 recordings were obtained and analysed. A four factor analysis of variance (MANOVA) was employed to check the significance of the influence of four factors (local GMA level; sequence of the days of measurements covering up to 3 days before and after geomagnetic storms; sex and the presence of medication) on the physiological parameters under consideration. Post hoc analysis was performed to elicit the significance of differences in the factors' levels. Arterial bp was found to increase with the increase of the GMA level, and systolic and diastolic bp were found to increase significantly from the day before till the second day after the geomagnetic storm. These effects were present irrespective of sex and medication.

Blood Pressure↗
PubMed1997

Analysis of heart rate variability during short-term space flight.

The heart rate (h.r.) of normal healthy subjects varies in rest, under high-load conditions and in pathology. The heart rate variability (h.r.v.) integrates many mechanisms in- and outside the central nervous system, which influence and regulate the h.r. Statistical methods have been used to obtain additional information concerning the diagnostic capabilities h.r.v., the correlation between ECG R-R intervals and their variability and the prognostic significance of h.r.v. The benefits of modification of h.r.v. are not well known. In our previous study the h.r.v. of astronauts before, during and after long-term space flight (seven months) was examined. In this study we make analysis of h.r.v. in wake and sleep in different phases during a short-time space flight (9 days) of the Bulgarian astronaut A.A. in 1988.

Autonomic Nervous System↗
PubMed1992

[Sleep as a restorative process under extreme exposure conditions].

In 40 aquanauts, a prolonged stay under increased pressure (11 to 46 kgs/cm2) of the oxygen-helium-nitrogen mixture did not affect the average duration of sleep. Slow-wave sleep, mostly its 3 rd and 4 th stages, and paradoxical sleep were significantly decreased whereas the light sleep/profound sleep ratio increased. The cyclic structure of sleep became altered. The longer the exposure to high pressure led to an augmentation of the slow-wave sleep and REM-phase, but the normal cycles terminating with a REM-phase could not be formed during the experiment.

Adult↗
PubMed1980

[Bloodless method for measuring the diastolic arterial pressure in rats].

A modification of an apparatus for undirect bloodless measurement of the arterial blood pressure (BP) in the tail of small laboratory animals (rats) is described. The device consists of a 3-channel ECG apparatus (C3a), connected with a blood pressure recorder(R67z/32) with an osciliscope (R17e) for visual checking of blood pressure. Criteria as well as possibility for measuring not only the systolic, but also the diastolic level of the blood pressure are indicated due to the great sensitivity of the device. It is pointed out that the coefficient of variation (3,58% for the systole and 5,95% for the diastole) is very low which confirms the reliability of the method. The results of a continuous (12 months) dynamic follow-up of the systolic and diastolic blood pressure of normotensive (NWR) and spontaneously hypertensive rats (SHR) are also reported. The authors conclude that the results could be used as normatyves and as indices for the range of the systolic and diastolic blood pressure of NWR and SHR aged 1 to 12 months, since no data about the diastolic blood pressure of rats are available so far in the literature.

Aging↗
PubMed1976

[Determination of free and protein bound cortisol, transcortin binding capacity and adrenocorticotropic hormone in the plasma of patients with hypertension].

The total non-conjugated plasma cortisol in 60 patients with hypertension disease (HD)is 17.5 mkg/ml. The free non-conjugated cortisol represents 8.45 per cent of the total - 1,5 mkg%, considerably (p less than 0.0001) higher than that in healthy subjects. Protein conjugated cortisol is 16.0 mkg%. The bounding capacity of transcortin the plasma of hypertonics is considerably decreased (p less than 0.0001) - 15.8 mkg (in healthy - 18.5 mkg) per 100 ml. ACTH level in the plasma of patients with HD is 32.0 pg/ml, considerably higher than that in healthy (25.8 pg/ml, p less than 0.0001). The elevation of the biologically active cortisol fraction in plasma of hypertonics is a function both of hypothalamo-hypopheseal stimulation and of transcortin level. That latent hypercortisolism is admitted to be manifestation of hypothalamo - hypopheseal superstimulation by increased ACTH secretion, in case of confirmed cerebro-hypothalamic disturbances in patients with hypertension disease.

Adolescent↗
PubMed1976

[Cortisol secretion rate (CSR) in hypertension and endocrine patients].

With the method of isotope dilution the circadian cortisol secretion was determined in 22 patients with hypertonic disease--28.35 mg/24 h, elevated versus CSR in healthy subjects-16.63 mg/24 h. CSR is elevated also in 5 patients with bilateral adenocortical hyperplasia and with suprarenal cancer. The patients with diencephalic syndrome, progressing according to the type of Cushing disease have elevated absolute values of CSR, but recalculated per square meter of body surface and per gram creatineine excreted in 24 h-CSR proved to be normal-about 12 mg/24 h.

Adrenal Cortex Neoplasms↗
PubMedDate not supplied

[The evoked brain activity during hyperbaric exposure].

Changes of amplitude-temporal parameters of visual evoked potentials (VEPs) under hyperbaric action testify to reconstruction of the activity of functional brain systems participating in the generation of responses to light stimulation. The revealed EP changes depend both on conditions of hyperbarism and on individual characteristics of subjects. The parameters of VEPs may manifest the estimation of common functional state under prolonged extreme influences.

Atmosphere Exposure Chambers↗