Biomedical subjects

I Sugano

Publications and source records attributed to I Sugano.

58 records · Page 4Linked to original sources

PubMedDate not supplied

Ultrastructural study of a perineurioma.

A case of soft tissue tumor in the left brachialis muscle of a 49-year-old Japanese female patient was studied by electron microscopy. The tumor was diagnosed as intramuscular myxoma by light microscopy, but electron microscopic observation revealed that the tumor almost entirely consisted of cells similar to normal perineurial cells. The tumor cells possessed long, slender cytoplasmic processes covered by well-developed but discontinuous basal laminae, clusters of pinocytotic vesicles, and infrequent intercellular junctions. Perineurial cells have also been observed in other peripheral nerve lesions: neurofibromas, nerve sheath myxomas, and localized hypertrophic neuropathies. However, the term "perineurioma" or "perineurial cell tumor" should be reserved for discrete tumorous masses that are almost entirely composed of perineurial cells without evidence of residual axons, Schwann cells, fibroblasts, or tactile corpusclelike structures. Perineurioma may represent a third category of peripheral nerve sheath tumors, ultrastructurally distinct from schwannomas and neurofibromas.

Female↗

PubMedDate not supplied

Prostate-specific antigen density adjusted for the transition zone for staging clinically localized prostate cancer in Japanese patients with intermediate serum prostate-specific antigen levels.

The prostate-specific antigen (PSA) density of the transition zone (PSATZ) in 45 prostate cancer patients who received radical prostatectomy with a PSA value of 4.1-10 ng/ml was determined to see whether PSATZ was useful in the prediction of extracapsular invasion of prostate cancer. The value of PSATZ for the detection of extracapsular invasion was compared with that of PSA and PSA density (PSAD). Thirty-one patients (68.9%) had pathologically organ confined cancer while 14 (31.1%) had extracapsular disease. Patients with organ confined tumor had significantly lower PSAD and PSATZ than those with non-organ confined tumor. PSATZ was superior to PSA when analyzed by receiver operating characteristics curves. In those patients with a cut-off value of 1.0 ng/ml per ml of transition zone volume, the PSATZ had a sensitivity of 43% and a specificity of 90% for prediction of extracapsular extension. The present study demonstrated that PSATZ was superior to PSA as a predictor of extracapsular invasion in intermediate PSA levels. Measurement of PSATZ may be of additional value to indicate the need for radical prostatectomy.

Adenocarcinoma↗

PubMedDate not supplied

Cytodiagnostic clues to primary retinoblastoma based on cytologic and histologic correlates of 39 enucleated eyes.

In 39 cases undergoing ocular enucleation, cytologic characteristics of primary intraocular retinoblastomas were examined in relation to histologic findings. Retinoblastoma cells occurred singly or in clusters within the associated necrotic debris. Calcific deposits were present in both cytologic and histologic specimens. Portions of capillaries with perivascular tumor infiltrates were identified as pseudorosettes. Wright rosettes were occasionally seen in poorly differentiated retinoblastomas. Flexner-Wintersteiner rosettes were uncommon; however, "mirror ball-like" clusters in cytologic materials correlated well with the rosettes and were a diagnostic clue. Cytomorphologically, the tumor cells could be divided into two types that reflected their histologic grading of differentiation. These findings are cytodiagnostic clues to the presence of retinoblastomas and can be helpful in the cytologic diagnosis.

Child↗

PubMedDate not supplied

Multivariate statistical analysis of bile cytology.

Cytologic features predictive of carcinoma in bile fluid were characterized by a review of 35 cases (22 malignant and 13 benign). Thirty-two cytologic variables were subjected to a stepwise multiple regression model to separate the criteria best suited to the benign versus malignant groups. Six key criteria were selected as useful indicators of malignancy: loss of honeycomb arrangement, enlarged nuclei, loss of polarity, bloody background, flat nuclei and cell-in-cell arrangement. Three or more of these criteria were observed in carcinoma cases more often than they were in noncancer cases (P < .01). By using these criteria, the overall sensitivity of diagnosing carcinoma by bile cytology was 86.4%, and the specificity was 76.9%.

Aged↗