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Biomedical subjects

I Szigetvári

Publications and source records attributed to I Szigetvári.

12 recordsLinked to original sources
PubMed1992

Tetraploidy in human placenta. A dilemma in molar and non-molar pregnancies.

17 cases of partial molar pregnancy were analysed cytogenetically by the direct-preparation method. Eight partial moles were triploid, 7 diploid/tetraploid mosaic, and 2 tetraploid. In the course of prenatal cytogenetic screening, out of 1,263 chorionic villus samplings, 2 tetraploid and 1 diploid/tetraploid cases were found. These cases of partial moles do not fit into the usual patterns of triploid partial moles. The findings presented here suggest that different causative factors may be involved in the origin of molar degenerations. These results also call to attention that tetraploidy is an existent and relatively common abnormality.

Adult↗
PubMed1990

Updated screening protocol for abortion services.

We performed 2976 first-trimester abortions at our outpatient center in 1986. In 16 cases (0.54%), products of conception could not be confirmed histologically, although history, bimanual pelvic examination, and urine pregnancy test were suggestive of pregnancy. In 1987-1988, we prospectively evaluated 6689 women presenting for first-trimester abortions. Adding sonography and a semiquantitative serum hCG test to our earlier protocol, we were able to date and locate accurately 6510 pregnancies (97.3%) at the first visit. The remaining 179 patients (2.7%) required only one follow-up visit for final evaluation. This protocol reduced the number of visits for accurate evaluation of pregnancy and eliminated the risk of unnecessary curettage and unplanned second-trimester abortions.

Abortion, Induced↗
PubMed1988

[Partial mole with lung metastases and multiple abnormalities of the fetus].

The authors report on a patient with partial mole, multiple malformations and lung metastases requiring chemotherapy. This case shows that the partial hydatidiform mole must therefore be carefully monitored by serial beta-hCG titres following evacuation to ensure the achievement of complete sustained remission.

Abnormalities, Multiple↗
PubMed1986

[Modern treatment of hydatidiform mole].

Authors describe their experiences in forty seven cases of molar pregnancy. Modern techniques (hCG beta-subunit radioimmunoassay, computerized tomography, pelvic angiography, ultrasonography, prophylactic chemotherapy) are described with regard to diagnosis and treatment of hydatidiform mole. The advantages of trophoblastic disease centers are emphasized.

Abortion, Induced↗
PubMed1976

The effect of allyloestrenol on human chorionic somatomammotropin synthesis of the placenta during normal pregnancy.

The effect of allyloestrenol on human chorionic somatomammotropin (HCS) level in healthy pregnant women in the fifth to eighth months of gestation has been studied by radioimmune techniques. The HCS level showed a significant increase within 10 to 12 days. According to the results, allyloestrenol exerts a stimulating effect on the placental steroids as well as on HCS production.

Allylestrenol↗
PubMedDate not supplied

Direct chromosomal preparation for studying hydatidiform moles.

This report describes a simple direct method to obtain chromosomes from hydatidiform moles. Of 24 moles, 20 have been successfully karyotyped by this method. Of the 20 cases, 14 were complete and six were partial. The karyotype of complete moles was invariably diploid. Three of the partial moles were triploid (69,XXX), but three showed diploid/tetraploid mosaicism.

Adolescent↗
PubMedDate not supplied

Effect of choriocarcinoma supernatant on natural killer and lymphokine-activated killer cell activity.

The effect of JEG-3 choriocarcinoma supernatant on human natural killer cell and lymphokine-activated killer cell activity was investigated. Choriocarcinoma supernatants from JEG-3 cell lines were obtained at the time of their optimal growth. K562 erythroblastoid cells were used as target cells for natural killer and lymphokine-activated killer cell mediated lysis in a 51Cr release assay. The choriocarcinoma supernatants had a significant dose-dependent suppressive effect on natural killer and lymphokine-activated killer cell activity. This suppression was more expressed at high effector: target cell ratios. Therefore, choriocarcinoma supernatants appear to have potent inhibitory effects on many aspects of cellular immunity, although, additional studies should be performed to further characterize and identify immunoregulatory molecule(s) in choriocarcinoma supernatants.

Choriocarcinoma↗