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I Takanami

Publications and source records attributed to I Takanami.

56 records · Page 4Linked to original sources
PubMedDate not supplied

Expression and prognostic value of the standard CD44 protein in pulmonary adenocarcinoma.

We examined immunohistochemically the expression of the standard form of CD44 (CD44S) tissue specimens from 164 patients with pulmonary adenocarcinoma. Of the 164 specimens, 79 (48%) expressed CD44S and the incidence of expression correlated with the tumor size. The prognosis for CD44S positive patients was poorer than that of CD44S negative patients. Our findings suggest that CD44S plays an important role in tumor progression and that CD44S expression is a useful prognostic marker for pulmonary adenocarcinomas.

Adenocarcinoma↗
PubMedDate not supplied

Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma.

The vascular endothelial growth factor (VEGF) and its receptor (Flt) protein expression was immunologically studied individually and in combination with the microvascular density (MVD) determined by the factor 8-related antigen (F8RA) and their prognostic value in 118 patients with a pulmonary adenocarcinoma. The presence of VEGF and Flt was associated with the MVD and prognosis. A reduced expression of both of VEGF and Flt correlated with less tumor angiogenesis and a better prognosis. Our findings suggest that VEGF and Flt expressions play an important role in tumor angiogenesis and that the VEGF and Flt coexpression promotes angiogenesis and metastasis in pulmonary adenocarcinoma.

Adenocarcinoma↗