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Biomedical subjects

I V Novikova

Publications and source records attributed to I V Novikova.

26 records · Page 2Linked to original sources
PubMed1985

[Hormonal regulation of the hemostasis system in patients with ischemic heart disease during emotional stress].

A total of 75 patients were examined, suffering from various forms of coronary heart disease (CHD) in conditions of emotional stress (ES). It was found that, as the blood anticoagulant activity and fibrinolysis are intensified in CHD patients in response to ES, the catecholamone effect on the blood coagulation inhibitors is decreased, the correlation between these parameters remaining high. In some patients decrease of the blood anticoagulant activity and fibrinolysis depression are observed in response to ES; decreased blood catecholamine concentrations were detected in the presence of high hydrocortisonemia, weakened hormonal effects, and emergence of negative correlation between these effects and the hemostatic system anticoagulant parameters, that evidences exhausted capacity of the anticoagulant system to defense activation.

Adrenocorticotropic Hormone↗
PubMed1985

[Interaction of adrenocorticotropic hormone, cortisol and insulin during emotional tension among ischemic heart disease patients].

Blood levels of the adenocorticotrophic hormone (ACTH), cortisol and insulin were measured in normal subjects and patients with different forms of coronary heart disease (CHD), aged 35 to 60 years and showing no signs of diabetes mellitus, obesity and arterial hypertension, under simulated emotional stress. The majority of the patients, particularly those with unfavorable course of the CHD, showed stress-induced disturbances of hormonal control due to depressed insulin levels in the presence of an insignificant ACTH increment and high cortisolemia. Hormonal rations were shown to be of predictive value in stress-exposed normal subjects and coronary patients alike.

Adrenocorticotropic Hormone↗
PubMed1985

[Effect of emotional tension on intravascular coagulation in patients with angiographically established ischemic heart disease].

The effect of simulated emotional stress (ES) on the platelet/vascular and plasma components of the hemostatic system was examined in normal subjects and coronary patients. In coronary patients, prestress hemostatic platelet/vascular and plasma factors were disturbed, their blood showing a tendency to activated intravascular coagulation. Stress further increased the blood thrombogenic potential of coronary patients, causing intravascular coagulation as evidenced by declining cAMP/cHMP ratio, enhanced release of soluble fibrin and fibrinogen-fibrin degradation products (FDPs), and reduced antithrombin III.

Adult↗
PubMed1984

[Changes in the hemostatic system and the progression of arteriosclerosis in ischemic heart disease patients].

The effect of standardized mental stress on the hemostatic system was studied in 160 patients with coronary heart disease. The diagnosis of coronary atherosclerosis was documented by selective coronary angiographic findings. Emotional tension was modelled using the method of counting with interswitching in conditions of time deficit, irritating light and sound signals, as well as critical remarks about the work performed. According to the protective-adaptive activation of the anti-clotting system, the patients were divided into two groups: 1 with activation of heparin activity of the blood and fibrinolysis, 2 with depressed fibrinolysis and lowered blood heparin. Prior to the onset of the study the patients of both groups exhibited hypercoagulation as compared with the control group. The maximum degree of hypercoagulation was observed in the second group patients. Hypercoagulative changes both at rest and under stress were shown to depend on the degree of coronary artery damage.

Adult↗
PubMed1984

[Effect of emotional stress on the system of hemostasis in patients with coronary arteriosclerosis].

Under conditions of experimentally induced psychic stress, the changes were studied in the activity of the sympatheticoadrenal system and the thrombocytic-vascular and the plasmic links of the hemostatic system. Ninety-seven men aged 35-61 years and suffering from coronary heart disease without hypertension and circulation insufficiency were studied. The diagnosis of coronary atherosclerosis was confirmed by selestive coronary angiography. Hypercatecholaminemia and a hypercoagulatory state were elicited prior to the investigation. According to the adaptive-protective activation of the anticoagulation system, in particular heparin activation, the patients were divided into two groups: a favourable one, characterized by the adequate protective activation of the anticlotting system, and an unfavourable one, characterized by the depression of the anticoagulation system and the depletion of the sympatheticoadrenal system.

Adult↗