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I V Proshina

Publications and source records attributed to I V Proshina.

30 records · Page 2Linked to original sources
PubMedDate not supplied

[Effect of the hyperbaric oxygenation of animals and man on mitochondrial function in their tissues (based on EPR study data)].

The ration of differential intensities of EPR signal of free endogenous radicals of semiquinone type and iron-sulfur proteins recorded at the temperature of liquid nitrogen in tissues (R index) is proposed as a criterion for estimation of changes in the functional state of mitochondria in human and animal tissues treated with hyperbaric oxygenation (HBO). The increase in R value was observed in hearts of intact mice and rabbits treated with HBO in near-toxic doses. This indicates a shift in mitochondria redox state towards oxidation. The above effect was not observed in mitochondria from intact zone of myocardium in animals with experimental infarction, and the numbers of mitochondria in the tissue increased after HBO. HBO treatment of women with pathological pregnancy leads to the decrease in R value for placental mitochondria.

Animals↗
PubMedDate not supplied

[Variants of intravenous anesthesia during artificial termination of pregnancy].

The use of anesthetics, analgesics and nootrops in various combinations has been analysed in 270 somatically healthy women during termination of pregnancy. The use of calipsol in combination with diazepam or pipolphen is recommended. A concomitant use of nootropil has a marked positive effect on the postanesthesia period, minimizing hallucinations. Adequate anesthesia is achieved by using a narcotic analgesic dipidalor in combination with N2O inhalation or reduced doses of calipsol or barbiturates.

Abortion, Induced↗
PubMedDate not supplied

[Changes in the amine oxidase activity of human serum during different types of anesthesia and hyperbaric oxygenation].

Some types of anesthesia, used usually in labor anesthesia (sodium hydroxybutyrate, lexir) or in abdominal delivery (neuroleptanesthesia, cetalar narcosis, electroanesthesia) did not affect distinctly the activity of amine oxidases in blood sera of women in labor and of fetus. In some groups of women in labor the neonates were found, blood serum of which exhibited high activity of diamine oxidase, not observed in normal state. A slight decrease in deamination of benzylamine (20%) and 4-nitrobenzylamine (30%) was observed in patients with gynecological diseases within 2 and 3 days after operations. If intestinal paresis developed in the patients within the postoperational period deamination of these substrates was decreased by 75-80% in blood sera. After 2-4 courses of hyperbaric oxygenation a slight but statistically distinct decrease (by 22-25%) in the rate of deamination of benzylamine and 4-nitrobenzylamine was found in blood sera of the patients.

Adult↗
PubMedDate not supplied

[Pharmacokinetics and pharmacodynamics of thiopental sodium in pregnant women during cesarean section].

Comparative study of thiopental pharmacokinetics and hemodynamics has been conducted in two groups of pregnant women subjected to planned cesarean section. Group I consisted of 6 women (thiopental dose 8.0 mg/kg was combined with components of neuroleptanalgesia), group II consisted of 7 women (the drug dose 4.68 mg/kg was combined with moradol analgesia). Dose-dependent differences in pharmacokinetic regularities of sodium thiopental in the groups compared have been revealed. Moradol did not cause the drug accumulation in the bodies of mother and fetus. The higher Apgar score was characteristic of the newborns from group II. Adequate anesthesia in pregnant women from group II was due to the potentiating effect of moradol. In both groups a correlation has been established between pharmacokinetic parameters and hemodynamic changes, as well as between sodium thiopental concentration in maternal and umbilical blood and pharmacokinetic parameters.

Adult↗
PubMedDate not supplied

[Energy expenditures in patients with insulin-dependent diabetes mellitus in a hospital and ambulatory environment (computer analysis)].

Original computer programs for assessment of energetic value of nutrition and daily energy expenditures of man based on physical activity protocols have been developed. The programs were tried in 16 patients with insulin-dependent diabetes, and essential individual differences from tentative table estimations of energy expenditures were detected. Correlations between treatment efficacy and individual energy expenditures of patients were observed; a moderate deficit of nutrition calories was found more detrimental for metabolic control than their moderate excess. The regularities detected even in such a nonrepresentative sample permit us evaluate high the potentialities and significance of the suggested method for assessment of energy expenditures.

Adolescent↗
PubMedDate not supplied

[The pharmacokinetic and pharmacodynamic characteristics of moradol in parturients during obstetrical analgesia].

Pharmacokinetic and pharmacodynamic monitoring of moradol (2 mg) given to 16 somatically healthy parturients during analgesia of spontaneous labor has identified 2 groups of patients who significantly differed in kinetic characteristics and in the drug's ability to penetrate through the placenta barrier. At the same time there were no significant differences in autonomic nervous function and central hemodynamics after intravenous moradol analgesia. The newborns from the two groups had identical high scores (8-9). Moradol produced an adequate analgesic effects in all parturients, reaching its peak at min 30-45 and lasting up to 2 hours. There was a high correlation between the plasma drug concentration and pharmacodynamic indices in parturients.

Adult↗