[Experimental study of toxic properties of silicon tetrafluoride].
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Administration, Inhalation↗
Biomedical subjects
I V Serebriakova
Publications and source records attributed to I V Serebriakova.
[Adaptation to chemical mutagens].
Pre-adaptation of normal and tumor cells to the action of methylnitrosourea was studied. To attain these ends, a single low dose (10 mg/kg) was administered to animals two hours prior to the administration of main therapeutic dose (100 mg/kg) and the number of chromosomal rearrangements was determined. A significant decrease in translocation incidence was observed in metaphases of Ehrlich-ICP ascitic strain. Similar results were obtained on cells of murine bone marrow. The mechanisms of pre-adaptation to the action is discussed.
Abdominal Neoplasms↗