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PubMed · 1447421

[Adaptation to chemical mutagens].

I V Serebriakova·M M Fomina·G G Poroshenko
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Abstract

Pre-adaptation of normal and tumor cells to the action of methylnitrosourea was studied. To attain these ends, a single low dose (10 mg/kg) was administered to animals two hours prior to the administration of main therapeutic dose (100 mg/kg) and the number of chromosomal rearrangements was determined. A significant decrease in translocation incidence was observed in metaphases of Ehrlich-ICP ascitic strain. Similar results were obtained on cells of murine bone marrow. The mechanisms of pre-adaptation to the action is discussed.

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Abdominal NeoplasmsAdaptation, PhysiologicalAnimalsBone MarrowCarcinoma, Ehrlich TumorCells, CulturedChromosome AberrationsDose-Response Relationship, DrugMethylnitrosoureaMiceMice, Inbred StrainsMicronucleus TestsMutagensNeoplasm TransplantationTime FactorsTumor Cells, CulturedComparative StudyEnglish AbstractJournal Article

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I V Serebriakova, M M Fomina, G G Poroshenko. [Adaptation to chemical mutagens].. https://pubmed.ncbi.nlm.nih.gov/1447421/

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