PubMed Health⌕ Search

Biomedical subjects

Iu F Krylov

Publications and source records attributed to Iu F Krylov.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Change in carbohydrate metabolism, secretion of insulin and glucagon in normoglycemic rats during administration of various doses of nicotinamide].

Development of hypoglycemia, a slight decrease in concentration of glucagon in blood as well as increase in activity of malate-and glucose-6-phosphate dehydrogenases in liver cytosol were detected in rats injected subcutaneously with nicotinamide at a dose of 31.25 mg/kg 6 hrs before decapitation. Increase of the single dose up to 125 mg/kg caused hypoglycemia, distinct increase in concentration of insulin and glucagon in blood plasma simultaneously with a pronounced inhibition of the enzymatic activity in liver tissue. Effect of nicotinamide on carbohydrate metabolism appears to have a dissimilar character depending on the drug dose: its small doses accelerated utilization and oxidation of glucose but did not affect the secretion of insulin and glucagon.

Animals↗
PubMedDate not supplied

[Methodologic problems of pharmacokinetics].

The subject of pharmacokinetics, method of research, aims and tasks of fundamental and applied aspects, place and importance for pharmacology are discussed. Discrepancy between a high scientific potential of pharmacokinetics and a low practical realization are analyzed, priority trends of future research are formulated.

Animals↗
PubMedDate not supplied

[Effect of nicotinamide on body glucose utilization in animals].

A single administration of nicotinamide (62.5 mg/kg) was found to enhance the relative activity of exogenous insulin, to decrease glucose level in the peripheral blood, to increase the activity of malate dehydrogenase and glucose-6-phosphate dehydrogenase in the liver cytosol in intact mice and to increase the rate of exogenous glucose utilization in rabbits. The character of nicotinamide effect on carbohydrate metabolism in intact animals is suggested to be dose-dependent. When administered in low doses, the drug increases tissue sensitivity to endo- and exogenous insulin.

Animals↗
PubMedDate not supplied

[Activity of antifibrinolytics when administered using a direct current].

Tests conducted on rabbits demonstrated a high effectiveness of fibrinolysis inhibitos (tracilol, E-aminocapronic acid) with their electrophoresis as compared with their intravenous administration. The absence of any influence of direct current on the activity of contrical, tracilol and E-ACA was ascertained.

Aminocaproic Acid↗
PubMedDate not supplied

[Metabolic products of methandrostenolone in the body of white rats studied by high-performance liquid chromatography].

Metabolism of the anabolic steroidal hormone methandrostenolone in Wistar rats was studied by high performance liquid chromatography (HPLC) and redioisotope techniques. The conditions for isolation of methandrostenolone metabolites by HPLC were developed. Reduction of the double bonds was shown to be an early stage in methandrostenolone biotransformation. The main portion of the metabolites was excreted with urine as glucuronide conjugates. No sulfoesters were found.

Animals↗
PubMedDate not supplied

[Dynamic distribution of methandrostenolone in the body of white rats].

Dynamics of distribution of anabolic steroidal hormone methandrostenolone and routes of its elimination from the organism of Wistar rats were studied by using methods of radioisotopes and high-performance liquid chromatography. Methandrostenolone metabolites were shown to be excreted mainly in the urine. Methandrostenolone metabolism is a complicated process in the course of which redistribution of metabolites among various organs occurs. The anabolic effect of methandrostenolone is supposed to be due to the formation of its metabolites.

Animals↗
PubMedDate not supplied

[Hormonal metabolic status of the human body under the conditions of the Far North].

The concentrations of hormones (ACTH, cortisol, aldosterone, thyrotrophin, thyroxine, triiodothyronine, growth hormone, insulin, prolactin and testosterone), electrolytes (Na and K) as well as glucose and triglycerides were measured in 10 athletes who made a 380 km ski expedition in the Far North at ambient temperatures of -32 to -34 degrees C. Human adaptation to the geographic and climatic conditions of high latitudes was accompanied by noticeable changes in the incretory function of the adenopituitary, thyroid gland, adrenals and gonads. The data obtained indicate that a ski trip in the Far North produces a distinct stress with physical and cold components being predominant.

Adult↗
PubMedDate not supplied

[Participation of cyclic nucleotides in the mechanism of regulation of the tissue pool of coenzyme A and the acetylizing capacity of rats].

cAMP and dibutyryl-cAMP were shown to increase the pool of CoA (or all the pantothenic coenzymes) in rat liver tissue, especially after treatment of the animals with 4-phosphopantothenate but not with pantethine. As shown by experiment with inhibitors of protein synthesis (actinomycin D, actidion, chloramphenicol) immediate c-AMP-dependent stimulation of the biogenesis of pantothenic coenzymes occurred rather from their precursors than due to induction of enzymes, participating in the biogenesis, or to destruction of the pantothenic coenzymes. Experiments with chloramphenicol exhibited that cAMP regulation of the biogenesis of pantothenic coenzymes in mitochondria was responsible mainly for the cellular pool of CoA and, partly, for the acetylation of para-aminobenzoic acid in tissues.

4-Aminobenzoic Acid↗
PubMedDate not supplied

[Microbiological method of determining cyanocobalamin in tissues and finished drugs made from animal raw materials].

An assay for cyanocobalamin with the use of the test microorganism E. coli, mutant ATCC 9637, is offered. The measurement of the content of cyanocobalamin in the blood serum and liver of intact rats after intraperitoneal drug injection demonstrated its content to reach a maximum 30 minutes after injection and to depend on the dose. When given in doses 100 and 400 micrograms/kg, the drug dose in the serum amounted to 82 and 261 ng/g, respectively, and in the liver to 80 and 259 ng/g. The method is readily reproducible, does not require the observance of strict aseptics, it is economical and time-saving.

Animals↗
PubMedDate not supplied

[Effect of aggregation inhibitors on thrombocyte enzymatic activity].

Experiments on rabbits proved that amidopyrin, sulphatizonicotinoilamine-guanidine, chlorpromazine, triphthazine, euphylline and tedamine inhibit aggregation of thrombocytes and unidirectionally have an effect on the carbohydrate metabolism enzymes in these cells, both in vitro and in vivo following their single and coursewise introduction. They also activate the lactate- and glyceraldehide-3-phosphate-dehydrogenase and reduce the activity of glucose-6-phosphate-dehydrogenase.

Aminophylline↗
PubMedDate not supplied

[Effect of amidine and guanidine derivatives on thrombocyte aggregation].

The capacity of 25 different amidines, guanidines and biguanidines to suppress the thrombocytes aggregation, induced by adenosinodiphosphate, was studied. Good prospects of a search for antiaggregation agents in this series of compounds are shown. N-benzyl-N1-propionylguanidine was found to reduce by more than 4 times the induced adhesiveness of the blood platelets.

Amidines↗
PubMedDate not supplied

[Acetylation of sulfadimezine and ethazole in rats].

The paper is concerned with studies into acetylation of sulfadimezine (S) in Wistar, August and random-bred rats and into that of ethazole in Wistar rats. Age-associated differences in S acetylation were examined in random-bred animals and the effect of phenobarbital on S acetylation was investigated in Wistar and August rats. Interlinear differences as regards S acetylation were found to be absent in the presence of sexual dimorphism as to the sign under study: the females were disclosed to be rapid while males to be slow S acetylators. Administration of phenobarbital did not lead to appreciable changes in the rat acetylator phenotypes. However there was tendency towards retardation of S acetylation in both the strains and both sexes. No sexual dimorphism as regards S acetylation was found in sexually immature random-bred rats whose acetylator phenotypes do not differ from those of adult females, or the development of sexual dimorphism in sexually mature animals. No sexual dimorphism as regards ethazole acetylation was shown in Wistar rats.

Acetylation↗