Biomedical subjects
Publications and source records attributed to Iu V Krylov.
Elevated Cs levels in the liver, gall bladder, kidney and urinary bladder were identified by gamma-spectral assay in the victims of common and oncological pathologies who died in Vitebsk Region in 2000-2001. The nuclide concentrations were relatively higher in gall and urinary bladder tissues in both groups. No differences in Cs uptake were established.
The paper considers the principles of classification of chronic duodenitis. The current classification of chronic duodenitis may be divided into three parts: endoscopic, histological, and etiological. The characterizing terms of the endoscopic part are as follows: erythema, hemorrhages, atrophy, erosions, follicles. The endoscopic localization of duodenitis is as follows: proximal and distal portions (panduodenitis, including bulbitis in the proximal portion and postbulbitis in the distal portion, palpilitis). The nonspecific terms of the histological part are as follows: activity, inflammation, and atrophy. Its specific terms are: ventricular metaplasia, ventricular heterotopia, Helicobacter pylori, granulomas, lymphatic follicles, eosinophilic infiltration, lymphocytic infiltration. The following morphological categories of duodenitis are: nonatrophic, nodular, granulomatous, eosinophilic, and lymphocytic. The morphological localization of duodenitis is as follows: proximal and distal portions (panduodenitis, including bulbitis in the proximal portion and postbulbitis in the distal portion). The following degrees of its severity are: none changes, mild, moderate, and sever. The types (etiological factors) of duodenitis are as follows: acid-associated, drug-dependent, toxic (eliminating), and isolated nonspecific (idiopathic). Its special forms are: H. pylori-induced, granulomatous (Crohn's disease, sarcoidosis), nodal (Crohn's disease, sarcoidosis, acid-associated diseases), eosinophilic (unspecified allergens), lymphocytic (gluten-induced).
Gamma spectometry was used to compare 137Cs levels in certain endocrine organs of victims of general and oncological diseases of different localizations. The radionuclide distribution in the thyroid, adrenals and pancreas was studied. Elevated concentrations were found in the endocrine system of cancer patients.
Ferritin was assayed by immunoradiometrical procedure in peritoneal fluid (26 patients with various ovarian pathologies) and gastric juice (18 patients with stomach cancer and 28 cases of gastric ulcer disease). It was found that diagnostic significance of ferritin measurements in peritoneal fluid in ovarian pathology is compromised by inflammation. Therefore, this marker cannot be used to differentiate between malignant and benign ovarian tumor. Single measurements of ferritin for detecting stomach ulcers were also diagnostically irrelevant since the data for stomach cancer and gastric ulcer exacerbation showed no significant difference.
137Cs-concentrations and distribution in internal organs and malignant tumor tissues from cadavers and patients operated on for cancer were identified by gamma spectrometry in clinics of Vitebsk Region. Non-uniform distribution patterns in different organs were registered, irrespective of the presence or absence of malignancy.
Development of noninvasive methods for the diagnosis of Helicobacter pylori infection is an important problem. We investigated the possibility of detecting the bacterium in gastric juice. Noninvasive methods (bacteriological and urease test) for detection of H. pylori in gastric aspiration biopsy specimens are proposed.
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The authors discuss the problem of improvement the noise factor prevention in aviation medicine. The analysis of the real acoustic load on aviation engineer specialists, performing maintenance of the modern military aircraft have been given. The authors show the importance of the approach to the aviation noise as an ecological significant factor, that means taking into account the acoustic load during work time as well as during rest-sleep periods. The authors suggested the advanced complex of the preventive measures for the purpose of optimization of the noise exposure on the aviation specialists.
Average diurnal doses of noise, received by aviation engineers servicing up-to-date aircrafts and living near air fields, were analyzed. The doses appeared to outnumber the normal values, especially during the work and the sleep. The examinees living in 1-2 km from air fields were proved to have significantly higher auditory thresholds for 1,000-8,000 Hz, in comparison with the examinees residing 5-6 km apart. The excessive noise associated with no occupational matters worsens the hearing restoration after the work, promotes accumulation of the hearing fatigue. Those facts were proved by experiments with audiometry and impedometry. The studies stressed the importance of aviation noise as ecologic factor.
Helicopter pilots exposed to excessive general vibration demonstrate changes of specific sensation (vibrotactile, vestibular, auditory), that could be signs of occupational disorder. Those changes are increased thresholds of vibrotactile sensation, lower vestibulovegetative stability, changed vestibulospinal reflexes, more common occurrence of consistent deafness for voice frequencies in comparison with jet aircraft pilots. Experimental vibration (50-1,800 (m/s2) 2 hour) caused no changes of the vibrotactile and auditory sensation, and the modified vestibular function could prove the increased vestibular reactivity.
Some theoretical aspects of the rehabilitation problem and its interaction with the problem of professional health of pilot have been discussed in this paper. The authors have proposed methodologic approaches to the essence of medical and professional rehabilitation; classification of the main directions and types of rehabilitation, the principles of its application in flying practice as well as the question about economic advisability have been studied. As the main lines of medical rehabilitation there suggests the nosologic, psychologic and physiologic, professional (singly) rehabilitation with consideration of the labile and base components of professional health of pilot. As the base principle of rehabilitation there advances an etiopathogenic approach to the use of different means and methods of rehabilitation treatment and correction of a changed functional state. General requirements upon provision of multilevel, differential, individual, accessible and adequate rehabilitation are formulated. The method to calculate the economic effect of rehabilitation measures at the expense of savings in costs of pilot personnel by increasing the flight longevity and decreasing the number of flights necessary for maintaining the given level of combat effectiveness is proposed. The classifier of the main directions and types of rehabilitation is presented.
Beta-I-MA and CEA concentration in gastric juice was studied in 74 patients with gastric pathology and healthy subjects. Elevated concentrations of beta-I-MA and CEA were found more often in the gastric juice of cancer patients and less often in that of patients without malignant pathology. No significant differences in the concentration of each antigen were found between the "cancer" and "polyp" groups. The combined use of the two test procedures was shown to sufficiently complement the CEA test. The difference in the probability of high concentrations of both antigens in gastric juice in cancer and low ones in other pathologies was highly significant (chi 2 = 15.3, p. 0.00015).
A method for abdominal ultrasonographic diagnosis of gastric cancer is suggested which includes evaluation of the gastric wall and regional lymph nodes, and search for distant metastases. Gastric tumors were visualized in 92.9% of cases. The procedure should be performed both in cancer suspects and cases with reliably established gastric neoplasm to assess local extent of tumor and detect regional and distant metastases.
The paper is concerned with the clinico-morphological analysis of the state of the art in diagnosing dysplasia and cancer of the stomach using gastric biopsy in a nononcological department of a regional hospital. Within three years, 13,459 gastroscopies were performed, 31.7% of them involving a biopsy. Cancer of the stomach was diagnosed in 87 patients including incipient form--in 8 (9.2%). Degree II-III dysplasia and alterations suspicious of cancer were identified in 49 while degree I-II dysplasia--in 180 cases. It is emphasized that patients with dysplasia including degree I-II lesions be followed using morphologic, endoscopic and clinical procedures.
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