Biomedical subjects

Iu V Nikitchenko

Publications and source records attributed to Iu V Nikitchenko.

20 records · Page 2Linked to original sources

PubMedDate not supplied

[Activation of membrane lipid peroxidation in the liver of young and old rats by thyroxine and actinomycin D].

Thyroxine and actinomycin D evoke activation of enzymatic peroxide oxidation of membrane lipids in the liver mitochondria and microsomes 24 hours after their separate or combined administration to Wistar males rats. In young animals the thyroxine effect is less pronounced than in old ones. Activation of peroxidation of membrane lipids with thyroxine or actinomycin D is not additive. Thyroxine had no essential influence on the glutathione-S-transferase activity of mitochondrial and postmitochondrial fractions of liver homogenates which is higher in old animals.

Aging↗

PubMedDate not supplied

[Age characteristics of lipid peroxide oxidation induction in the rat liver during fasting].

The peroxide oxidation of lipids, both spontaneous and NADPH-induced, was studied in incubation of the liver homogenate postnuclear fraction for rats aged 1, 3, 12 and 24 months. Fasting increases significantly the rate of NADPH-dependent accumulation of malonic dialdehyde, the absolute growth value of which was almost the same in 1,3 and 24-month rats and higher than in the middle-aged animals. A relative increase in the lipid peroxide oxidation intensity during fasting as compared to the norm is more sharply pronounced in old rats.

Aging↗