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Biomedical subjects

J A Castillo

Publications and source records attributed to J A Castillo.

72 records · Page 4Linked to original sources
PubMed1991

Atherosclerosis in diabetes and hypertension. A comparative morphometric study of their progression using an atherometric system.

The three major epicardial coronary arteries of a set of 472 autopsy cases divided into four groups: a) non-diabetics and non-hypertensive, 322 subjects; b) hypertensive, 75 subjects; c) diabetics, 57 subjects and d) hypertensive and diabetic, 17 subjects, were studied. Classical pathomorphological procedures and an atherometric system (AS), suitable to characterize the atherosclerotic lesions, was used searching for differences between the level of atherosclerosis into these four groups and its eventual progression according to the time of evolution of these diseases. Raw data processing was full automated and some univariate and multivariate statistical procedures (means, standard deviations, ANOVA, MANOVA and principal components analysis) were performed using two commercial statistical packages: "NCSS" and "SYSTAT". The most remarkable findings were the following: Diabetes and hypertension have both strong impact upon the rate at which the atherosclerotic process takes place in subjects affected by these diseases. The time of evolution of both diseases correlates positively and independently of age with the velocity of the atherosclerotic process at the three coronary arteries. The impact of diabetes seems to be stronger and is particularly expressed by the severe plaques (Z) while the effect of hypertension is specially observable at the fibrous plaques (Y). There seems to be no significant interaction (synergism) between the two risk factors upon the measurement of the atherosclerotic lesions, that is, they have an additive effect. Two simple underlying factors can be used to account for interindividual differences. These two factors are "dominated", respectively, by fibrous (Y) and severe plaques (Z).

Analysis of Variance↗
PubMed1991

[The integration of psychotherapies: clinical and theoretical perspectives].

An emphasis is placed on the dual perspective--clinical and theoretical alike--from which integrative approaches arising in the field of Psychotherapy can be envisioned. Research should go along two particular lines: a) All elements that different treatments share, and b) The change processes such treatments are likely to give way to, in an effort to develop a consistent theoretical and epistemological framework. While awaiting for coherent developments to take place, however, a professional psychotherapist should avoid resorting to technical eclecticism on the one hand. On the other hand he or she should try to overcome the limitations of his or her own theory through a collaboration work with otherwise-oriented fellow therapists.

Psychotherapy↗
PubMed1989

Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation.

The records of 92 asthmatics who underwent mechanical ventilation were reviewed. In seven patients (8%) the severe attack was precipitated by a non-steroidal anti-inflammatory drug (NSAID); one of these patients died. Five of the cases had a history of asthmatic attacks provoked by NSAIDs; whilst in two the severe attack requiring mechanical ventilation was the first manifestation of NSAID-intolerance. In two patients the NSAID had been prescribed by their physicians. Another aspirin-intolerant patient, a general practitioner, self-administered a NSAID. The sudden attack in another patient was precipitated by a preparation which contains aspirin and is usually recommended for indigestion. In the fatal case the attack was provoked by a capsule containing aspirin, which had been given by a herbalist. Unlike other reports, we found that NSAID-intolerance is a frequent provoking factor in severe acute asthma requiring mechanical ventilation. Inadequate investigation of precipitating factors in asthmatics with severe sudden attacks is a possible reason why this phenomenon is underreported.

Adolescent↗
PubMed1988

Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study.

The effect of a fish oil enriched diet containing about 3 g of eicosapentaenoic acid was studied in 10 patients with aspirin intolerant asthma. Subjects were studied during six weeks on a control diet followed by six weeks on the fish oil diet in a single blind study design. They were asked to record their peak expiratory flow (PEF) twice daily, bronchodilator and steroid doses, and subjective ratings of pulmonary symptoms on diary cards. There were no significant changes in symptom scores over the six weeks of either the control diet or the fish oil diet. PEF values, however, were significantly lower during the fifth and sixth week of the fish oil diet than during the control diet (308 v 262 l/min week 5 and 306 v 256 l/min week 6). Bronchodilator usage was also greater during the fifth and sixth week of the fish oil diet than during the control period (12.0 v 7.4 and 13.0 v 7.4 puffs a day in weeks 5 and 6). This pilot study suggests that fish diets may have a deleterious effect on patients with aspirin intolerant asthma.

Adult↗
PubMed1980

Uhl's anomaly associated with pulmonary atresia.

We present a case of Uhl's anomaly associated with atresia of the pulmonary valve. The rarity of this association is noteworthy, only three cases having previously been published. Our case presents the peculiarity of a patient with a normal tricuspid valve.

Female↗
PubMed1979

[Parachute tricuspid valve associated with Fallot's tetralogy].

Parachute deformity of the tricuspid valve was observed with a severe form of Fallot's Tetralogy with pulmonary atresia in a newborn. Signs of tricuspid stenosis (peripheral oedema, right atrial dilatation, hepatomegaly and conduction defects) were associated with the clinical signs of the principal malformation (severe hypoxaemia). To our knowledge, this is the first reported case of parachute deformity of the tricuspid valve.

Humans↗
PubMed1979

[Right ventricle with double outlet and intact interventricular septum. Report of 1 case and review of the literature].

Double outlet right ventricle with an intact interventricular septum is an exceedingly rare malformation. Only six other cases have been found in the world literature. The clinical, electrocardiographic, radiological and anatomical features of this condition were reviewed on the occasion of the diagnosis of a new case. Cardiac catheterisation and angiography performed in only one other case is not definitive in the presence of mitral atresia.

Autopsy↗
PubMed1978

Intracardiac heterotopia--mesenchymal and endodermal.

A case is reported of an intracardiac 'epithelial heterotopia' with a predominant mesenchymal component. This is thought to have resulted from the differentiation of aberrant primitive cell(s) displaced into the heart during its development. Though microscopically resembling a myxoma, this lesion is clearly distinguished by the presence of glandular structures. The myxoid component exhibited a startling invasiveness which resulted in occlusion of the superior vena cava, causing symptoms very early in life and death at the age of 6 months.

Choristoma↗
PubMedDate not supplied

Infectivity of dogs naturally infected with Leishmania infantum to colonized Phlebotomus perniciosus.

A study was carried out on the infectivity to sandflies of 16 dogs naturally parasitized by Leishmania infantum. All dogs were seropositive and the parasite had been isolated from all except one. They were divided into 3 clinical groups: 5 asymptomatic, 4 oligosymptomatic, and 7 polysymptomatic dogs. The dogs were exposed to female Phlebotomus perniciosus from a local colony and 7 d later the fed females were dissected in order to determine their rate of infection. There was wide variability of the percentage of fed and infected sandflies within each clinical group of dogs, with no significant difference between the 3 groups; the infectivity to sandflies was independent of the extent of symptoms in the dogs.

Animals↗
PubMedDate not supplied

Desensitization in aspirin-sensitive asthmatics.

Tolerance to aspirin was induced in thirteen asthmatics with aspirin-intolerance. Starting with the lowest aspirin doses eliciting bronchospasm, the dose of aspirin was progressively increased up to a 1000 mg tolerance level. Tolerance was rapidly achieved when initial threshold doses were greater than 150 mg. Daily aspirin administration led to prolonged tolerance. Desensitization to aspirin may be useful in aspirin-sensitive asthmatic patients who require antiinflammatory or antithrombotic treatment.

Aspirin↗