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Biomedical subjects

J A Garrett

Publications and source records attributed to J A Garrett.

5 recordsLinked to original sources

Assessment criteria for diagnostic imaging technologies.

Expensive diagnostic imaging technologies need to be assessed. Assessment is most difficult with new technologies. Rapid technical change creates pressure for widespread provision because of apparently self-evident advantages. For the health care provider, technology assessment is of central importance. Timing is crucial; economic and clinical studies have to be carried out simultaneously; and studies must be broadly based. Assessment should be carried out only on properly selected technologies. Apart from picture archiving and communication systems, existing expensive diagnostic imaging technologies are now so mature that assessment is concerned mainly with costs and benefits. To be provided, a technology needs to be effective, economic, appropriate and needed. The history of computed tomography illustrates technology assessment from innovation to routine application. Technology assessment also provides essential guidance for equipment selection. Different regulations and controls, explicit or implicit, exist in different countries. There are special requirements for technology assessment in each country according to overall health requirements and policies. The main contemporary challenges are the correct selection of equipment for assessment, and the development of predictive methods of assessment.

Diagnostic Imaging

Meeting the international standard ISO 9002/BS5750.

In this paper we outline the rationale for applying British Standard BS5750 to a medical equipment management service and introduce some of the concepts of the standard as they apply to this field. We see this application as essential in today's legal and commercial environment and indicate the ways in which this work is being carried forward by the Medical Equipment Management Organisation into total quality management systems.

Equipment Safety

Hearing loss and otitis media on Guam: impact of professional services.

In less than two decades, there has been a dramatic reduction in the prevalence of otitis media and perforations among Guam's school-aged children. In addition, hearing loss due to chronic middle ear disease as a cause of disqualification from military service has dropped from a first rank order cause to next-to-last. However, there has been no reduction in the prevalence of otitis media in the preschool population. The reduction in chronic ear disease is the result of improved access to primary care, intensive hearing screening, wide availability of audiologic diagnostic and follow-up services, and comprehensive otologic care. It is essential that these services continue to be available to Guam's children to avoid a reversal of these dramatic gains. Attention must now focus on how to achieve similar gains for Micronesian children who remain restricted in their access to these resources.

Adolescent

Optimal conditions for the growth of malignant human and animal cell populations in immunosuppressed mice.

Immunosuppressed mice have been used to support the growth of xenogeneic human and animal malignant cell populations. The optimal conditions for tumor growth are neonatal thymectomy coupled with antithymocyte serum or thymectomy, followed by whole-body irradiation and bone marrow reconstitution. When mice are inoculated with a mixture of normal and malignant cells, the malignant cells have a selective advantage. No such selectivity is found when the mixed populations are grown in vitro. Human tumors may also be grown in immunosuppressed mice. These tumors retain the organization of the original tumor in the human host. The advantages of this system to cancer researchers are discussed.

Animals