PubMed Health⌕ Search

Biomedical subjects

J AXELROD

Publications and source records attributed to J AXELROD.

At least 37 records · Page 2Linked to original sources

MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT.

In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of melatonin-synthesizing-enzyme (hydroxyindole-0-methyl transferase) in the pineal gland, but no change in the activity of monoamine oxidase. Since melatonin appears to have a hormonal role in mammals, and its synthesis is confined to the pineal gland, the inhibition of hydroxyindole-O-methyl transferase by light may constitute a mechanism of neuroendocrine regulation.

Animals↗