ENZYMIC OXIDATION OF EPINEPHRINE TO ADRENOCHROME BY THE SALIVARY GLAND.
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Biomedical subjects
Publications and source records attributed to J AXELROD.
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In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of melatonin-synthesizing-enzyme (hydroxyindole-0-methyl transferase) in the pineal gland, but no change in the activity of monoamine oxidase. Since melatonin appears to have a hormonal role in mammals, and its synthesis is confined to the pineal gland, the inhibition of hydroxyindole-O-methyl transferase by light may constitute a mechanism of neuroendocrine regulation.