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J AXELROD

Publications and source records attributed to J AXELROD.

At least 91 records · Page 5Linked to original sources

Enzymatic O-methylation of N-acetylserotonin to melatonin.

An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.

Acetylserotonin O-Methyltransferase↗