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Biomedical subjects

J AXELROD

Publications and source records attributed to J AXELROD.

At least 109 records · Page 6Linked to original sources
PubMed1959

Inhibitor of O-methylation of epinephrine and norepinephrine in vitro and in vivo.

Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse. Since pyrogallol also prolongs the physiological effects of epinephrine, it is suggested that catechol-O-methyl transferase terminates the actions of the catecholamine hormones.

Animals↗
PubMed1959

Blood-brain barrier for adrenaline.

The concentration of tritiumlabeled adrenaline was determined in various areas of cat brain after intravenous infusion. It did not exceed that expected from the blood content of the tissue except in the hypothalamus, where small but significant amounts of H(3)-adrenaline were found.

Animals↗