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J Basterra

Publications and source records attributed to J Basterra.

At least 55 records · Page 3Linked to original sources
PubMed1994

Laryngeal mucociliary transport: normal values and under the influence of anesthetics. An experimental study in rabbits.

The larynx is the point of confluence of all tracheobronchial secretions and of the particles trapped within them. A study is made of laryngeal mucociliary transport using charcoal particles in 8 anesthetized rabbits and in 8 more during the immediate postmortem period. Most secretions were found to reach the posterior commissure, and were then swallowed. In the immediate postmortem rabbits, mucociliary transport velocity was 3.59 +/- 1.23 mm/min., with a transport time of 4.62 +/- 1.5 min. In the 8 rabbits anesthetized with droperidol, diazepam and thiobarbital, transport was found to be significantly slowed (p = 0.001).

Anesthetics↗
PubMed1993

An isotopic study of nasal mucociliary transport in newborns: preliminary investigation.

The diagnosis of primary ciliary dyskinesia (PCD) depends on electron microscopic examination of cilia obtained from mucosal biopsies of the nasal turbinates or the trachea. This is an invasive, time-consuming, and expensive technique. The low incidence of this abnormality, the large number of infants and children with suggestive symptoms, and the lack of a reliable screening test make the decision to proceed with diagnostic biopsy a common problem in recurrent or chronic respiratory pediatric conditions. To improve this situation early in infancy, nasal mucociliary transport was evaluated in 10 normal newborns using the Tc-99m-labeled seroalbumin technique, and the results obtained were compared with those corresponding to a newborn with Kartagener's syndrome. Transport velocity in normal newborns was similar to that observed in older children and in adults, in contrast to the tracer immobility seen in the affected newborn. This technique is simple, safe, objective, and well tolerated in this age group and might be used as an early screening test to ruling out PCD.

Ciliary Motility Disorders↗
PubMed1993

Peptide-containing nerve fibers in human airways: distribution and coexistence pattern.

The occurrence, distribution and coexistence pattern of an array of neuropeptides and tyrosine hydroxylase in the human larynx, trachea, bronchi and lungs were studied by immunocytochemistry. A rich supply of nerve fibers containing vasoactive intestinal peptide (VIP) was seen close to blood vessels, glands and nonvascular smooth muscle. Pituitary adenylate cyclase-activating peptide (PACAP)-containing fibers were numerous among bundles of smooth muscle. Moderate numbers of helospectin-containing nerve fibers were seen in the nonvascular smooth muscle. The majority of neuropeptide Y (NPY)-containing fibers were located in the nonvascular smooth muscle; some fibers also occurred around blood vessels and glands. Substance P (SP) and calcitonin gene-related peptide (CGRP)-containing fibers were generally few and distributed beneath the epithelium, among bundles of smooth muscle, around blood vessels and glands. A conspicuous finding was the lack of SP- and CGRP-containing fibers within the respiratory epithelium. Galanin-containing nerve fibers were moderate in number among bundles of smooth muscle. Tyrosine hydroxylase-containing fibers were numerous around blood vessels and glands. The majority of the VIP-containing nerve fibers present in nonvascular smooth muscle also stored PACAP and helospectin. A subpopulation of VIP-containing fibers in both vascular and nonvascular smooth muscle and around glands stored NPY. Additionally, galanin was found to occur in many VIP-containing fibers located among bundles of smooth muscle.

Adrenergic Fibers↗
PubMed1993

Analysis of DNA content in supraglottic epidermoid carcinoma.

DNA analysis by flow cytometry is considered to be of prognostic value in epidermoid carcinoma of the head and neck. However, few and contradictory studies have been made on laryngeal carcinomas. We studied 48 epidermoid carcinomas in patients subjected to horizontal supraglottic laryngectomy with a 5-year- followup. The technique described by Hedley for fixated and paraffin-embedded tumors was used. Thirteen tumors were excluded on the grounds of presenting variation coefficients in excess of 10. Of the 35 cases analyzed, 28 (80%) were diploid and seven (20%) aneuploid. No correlation was observed between tumor ploidy and patient survival, recurrence, or any of the histopathological variables studied.

Adult↗
PubMed1993

Prognostic value of histopathological parameters in 51 supraglottic squamous cell carcinomas.

The prognosis for supraglottic squamous cell carcinomas is difficult to establish. A study of 19 histopathological parameters (14 from the primary tumor and 5 from the lymph node metastases) was undertaken in 51 supraglottic epidermoid carcinomas. All patients were subjected to supraglottic horizontal laryngectomy with bilateral functional neck dissection and postoperative radiotherapy. A discriminant analysis was performed to relate the different histopathological variables to 5-year survival. Capsule rupture and the number of metastatic lymph nodes were the only two parameters significantly related to survival (P < .01). Histopathology (in particular, lymph node metastases) proved more effective in predicting patient evolution than TNM staging.

Adult↗
PubMed1993

[The influence of age, sex and circadian rhythms on the nasal mucosal in the mucociliary clearance].

We have studied the nasal mucociliary transport in 115 normal persons between 5 and 85-years-old. Using vegetable charcoal powder method the transport time varies between 5 and 18 minutes. The mean transport time was 8.35 +/- 2.6 min. Transport time is not variable with age until sixty years, when transport slow down. The mucociliary clearance is faster in female (p = 0.018). In these individuals the transport time is less in the evening-hours (p = 0.01). In men no differences has been noted (p = 0.57).

Adolescent↗
PubMed1993

[Melanoma of the nasal cavity].

Presenting a case of nasal Melanoma, in a patient previously diagnosed and treated from Rhabdomyosarcoma of the same nasal cavity. In our Department has been treated with surgery plus thymostimulin (TP-1 Serono) after surgery. Subject reviewed and clinic features, diagnostic difficulties and nowadays immunotherapy commented.

Antibodies, Monoclonal↗
PubMed1993

[Kniest syndrome. An audiological study].

In this syndrome there is a disproportionate dwarfism with kyphoscoliosis, stiffness of the joints, minor facial dysmorphia, myopia and both conductive and sensorineural deafness in 50 percent of patients. It is a dominant autosomic heritable malady of unknown incidence, but both sexes seems equally affected. The patient's condition is diagnosed at birth, because of the short limbs and the enlargement of the joints. In the presented case, diagnosed at birth, the deafness was suppose to be transmissive, owing to the coexistence of a cleft palate, and consequently a grommet was inserted in the tympanum. Only afterwards, when the girl was 12 years old, the cochlear component of the hypoacusis fell in consideration.

Audiometry↗
PubMed1992

[Granular cell tumor (Abrikossoff's tumor). A review and our experience].

The low incidence of these tumors compelled the AA., after diagnosis of one of laryngeal sitting, to a review of the theme and its literature as well, particularly under the viewpoint of its histogenesis, which has been debatable up to lately. The report is complemented with the study of immunohistochemical tests for NHK, S-100 and specific neural enolase of the specimen.

Adult↗
PubMed1992

[Prognostic value of histopathological parameters in epidermoid carcinoma of the vocal cords in T-1 stage].

In this paper are studied macro- and microscopically, 14 histopathologic parameters belonging to 37 patients suffering from vocal cord squamous cell carcinoma, stage T-la. All patients were submitted to cordectomy and followed up during a 5 years term, as a minimum. A discriminant analysis was performed in order to establish the relation between histopathologic parameters and local failure. Only two of them were statistically significative (p < 0.01): the structural type and the differential degree of tumor cells. The histopathological study allowed the prediction of 82 percent of local recurrences.

Carcinoma, Squamous Cell↗
PubMed1991

Nasal mucociliary function in the normal newborn.

Nasal mucociliary transport has been studied using the seroalbumin-Tc99m radioisotope method in 10 adults and 10 normal newborns under 28 days of age. The mean transport velocity was 8 and 6 mm/min for the normal adults and newborns, respectively, with no significant differences between the two (P = 0.07).

Humans↗
PubMed1991

[Laryngocele. Report of a case of giant laryngocele associated with occult papillary carcinoma of the thyroid].

This gross laryngocele caused a chronic obstruction of the upper respiratory airway. Diagnosis become obvious because the aggravation of a chronic bronchopathy slightly developed, which run into a cor pulmonale chronic as well. Incidentally linked with a neck metastasis spread out from a hidden papillary carcinoma of the thyroid gland. The laryngocele was treated by extramucous lateral thyrotomy and the carcinoma removed through subtotal thyroidectomy.

Carcinoma, Papillary↗
PubMed1990

Nasal mucociliary function during the menstrual cycle in healthy women.

Nasal mucociliary transport time was studied in nine healthy women over the menstrual cycle using the vegetable charcoal powder technique. Three measurements were made at different points of the cycle: during the early follicular phase, periovulatory phase and luteal phase. The mean transport times were 10.1 +/- 3.50, 5.1 +/- 2.08 and 7.5 +/- 3.28 minutes, respectively. Transit was significantly accelerated during the periovulatory phase (p less than 0.01), when the seric estrogens are at their highest level.

Adult↗
PubMed1989

The autonomic innervation of the human vocal cord: neuropeptides.

Three methods have been used to study the sympathetic and parasympathetic innervation of the vocal cord: paraformaldehyde-induced fluorescence, electron microscopy, and the peroxidase-antiperoxidase technique. Each method has been successful in determining adrenergic fibers, autonomic endings, and the neuropeptides VIP and NPY, respectively. The close relationship between these neuropeptides and the autonomic endings (adrenergic and cholinergic), and the presence of the neuropeptides in the chorion of the vocal cord, around glands and vessels, gives new evidence that autonomic innervation plays a role in the functioning of this part of the larynx.

Humans↗
PubMed1989

The influence of anesthetics and vasoconstrictors on nasal mucociliary transport.

Nasal mucociliary transport time is studied in 38 healthy individuals using the charcoal dust technique, following topical application of a lidocaine solution in 10 cases, tetracaine in 11, and oxymetazoline in 17. The results show that lidocaine does not alter the transit time, whereas tetracaine increases it significantly; in turn, oxymetazoline progressively increases transit time, although this slowing is fully reversible 30 minutes after application.

Adult↗
PubMed1989

Vasoactive intestinal polypeptide and neuropeptide-Y, as possible mediators in laryngeal oedema. An immunofluorescence study.

Little attention has been paid to the autonomic innervation of the human vocal cord. Vasoactive intestinal polypeptide (VIP) and Neuropeptide-Y (NPY) are of interest because of their association with the autonomic nervous system. These neuropeptides have not been studied in the human vocal cord by immunofluorescence technique. Both neuropeptides were found in the connective tissue close to the basal layer of the mucosa, around glandular structures and arterial walls. Comments are made about the role these peptides might play in the physiopathology of vocal cord oedema.

Autonomic Nervous System↗