Biomedical subjects

J Belaisch

Publications and source records attributed to J Belaisch.

17 recordsLinked to original sources

PubMed1992

[Hermaphroditism and male pseudohermaphroditism].

In the human embryo, sex is all in the genes. Later on, the male and female sexual characters, which are products of the expression of all individual genomes, differentiate men from women. In this paper, the embryogenesis and morphology of true hermaphroditism and male pseudo-hermaphroditism are studied. These are intersexual states determined by errors in genital programme transmission. A relationship is established between the biochemical identification of substances secreted by the testis and the evolution of sexual characters. The genesis of sexual abnormalities according to the stage when the testicular deficit appears is envisaged. The clinical, anatomical, histological and biochemical aspects of these intersexual states are described.

3-Hydroxysteroid Dehydrogenases↗

PubMed1991

[Venous wall and sex hormones].

The effects of female sex hormones upon the veins of lower limbs are well-known particularly since women use widely estroprogestatives or progestatives drugs. The knowledge of the mechanism of action of hormones and particularly of steroids upon cells receptors has been dramatically improved and allowed to explain some endocrinologic states till now misunderstood. In return, intimate mechanism of the hormonal disturbances of venous function is still mysterious. The published studies are conflicting or radically inconsistent with basic notions of hormonal activity which seemed established. The presence of hormonal steroids receptors in endothelial cells from the rabbit aorta intima has been confirmed and the reality of these cytosolic receptors from the pelvic and lower limbs venous tissues has been demonstrated by biochemical methods in some publications. But other authors have pointed out the lack of these receptors on pelvic vessels by using immunohistochemical localization and discovered progesterone receptors in large vessels and myocardial fibers nuclei. Extremely fine effects of natural and synthetic estrogens, that coagulation specialists try to understand, are distorted by rough descriptions which only consider the peculiar but not whole therapeutic aspects. This problem is at the border of several specialties and synthesis have to be achieved. But before the year 2000 substantial progress will surely be carried out with regard to the importance of the lower limbs and genital sphere venous pathology for women (and also for men) and substantial therapeutic consequences will follow.

Animals↗

PubMed1988

Selective oocyte retrieval: a new approach to ovarian hyperstimulation.

Selective oocyte retrieval is a new approach to ovarian hyperstimulation (OHS) that prevents side effects of OHS and multiple pregnancies by puncturing most of the ovarian follicles 35 hours after hCG administration as in an IVF program. The remaining intact follicles can still result in a singleton or twin pregnancy. In three patients who presented a multiple follicular development, this technique resulted in two pregnancies; moreover, the retrieved oocytes were fertilized and the embryos frozen.

Female↗

PubMed1987

Morphological anomalies in the placentae of IVF pregnancies: preliminary report of a multicentric study.

Macroscopic characteristics of 100 fetal adnexae from pregnancies obtained by in-vitro fertilization and embryo transfer (IVF-ET) were compared with data for normal pregnancies taken from the literature. Material was obtained from 63 singleton, 15 twin, one triplet and one quadruplet pregnancies. The fetal and placental weights as well as the fetal:placental weight ratio were within the normal range for gestational age. Whilst placental morphology was normal, the insertion of the umbilical cord was frequently abnormal. Marginal (15%) and velamentous (14%) insertions of the umbilical cord were found more frequently than in a general obstetrical population (6% and 1% respectively). Excluding placentae from multiple pregnancies (which are known to have a higher incidence of abnormal cord insertion) the frequency did not decrease and remained significantly higher than in a normal population (P less than 0.01 and P less than 0.001, for marginal and velamentous insertion respectively). Abnormal insertion of the cord is of major clinical importance because of its association with vasa praevia and fetal haemorrhage (Benkiser Syndrome). Since this condition is thought to be caused by disturbed orientation of the blastocyst at implantation it is probably related to the IVF-ET procedure.

Embryo Implantation↗

PubMed1987