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Biomedical subjects

J Borowski

Publications and source records attributed to J Borowski.

At least 37 records · Page 2Linked to original sources
PubMed1985

Sensitivity testing of bacteria to ceftriaxone using discs with different amounts of antibiotic.

Studies were performed to compare the results of sensitivity testing of bacteria to ceftriaxone using discs containing 10, 20, 30 and 40 micrograms of the antibiotic. The highest correlation between diameters of zone inhibition and MIC values was found with discs containing 30 micrograms of ceftriaxone. The lowest percentage of false results was also obtained with 30 micrograms discs.

Bacteria↗
PubMed1985

The influence of some cephalosporins on immunological response.

The effect of cefotaxime and cephradine on the activity of some immune mechanisms was investigated in mice. It was found that cefotaxime in therapeutic doses did not affect the humoral and cellular immune response against sheep erythrocytes, whereas cephradine suppressed the humoral response in doses corresponding to those used for the treatment of patients. The response in vitro of mouse spleen lymphocytes to PHA was suppressed by both cephalosporins; however this occurred at therapeutic concentrations only in the case of cephradine. Neither cephalosporin affected the phagocytic and chemotactic activity of mouse peritoneal macrophages and rabbit microphages.

Animals↗
PubMed1985

The effect of phospholipids from Listeria monocytogenes and Aspergillus fumigatus on degradation of bacterial antigens by mouse peritoneal macrophages.

Investigations were carried out on an influence of phospholipids from L. monocytogenes and A. fumigatus on the degradation of Streptococcus faecalis cell walls by mouse peritoneal macrophages. It has been found, that macrophages from mice stimulated with phospholipids under studies degraded streptococcal cell walls labeled with DL-alanine-I-14C more efficiently than normal macrophages. Activated macrophages degraded also more rapidly antigenic structures of bacterial cell walls reacting with specific fluorescein-labeled antibodies. Moreover, the increase in activity of lysosomal acid hydrolases in stimulated macrophages was observed. The experiments performed suggest that increased ability of macrophages to degradation of bacterial antigens may be connected with a primary augmentation of lysosomal enzyme activity.

Animals↗
PubMed1984

Influence of phospholipids from Listeria monocytogenes and Aspergillus fumigatus on the bactericidal and fungicidal activity of mouse peritoneal macrophages.

Investigations were carried out on an influence of phospholipids from A. fumigatus and L. monocytogenes on the bactericidal and fungicidal activity of mouse peritoneal macrophages. L. monocytogenes bacilli and C. neoformans fungi served as the experimental microorganisms. Phospholipids from A. fumigatus and L. monocytogenes were shown to significantly increase macrophage activity under in vivo and in vitro conditions. This was accompanied by an intensified bactericidal and fungicidal activity of extracts from the lysosomal fraction of phagocyte examined. Phospholipid-stimulated macrophages were observed to liberate bactericidal factors into the culture fluid. Lymphocytes had no influence upon this process.

Animals↗