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Biomedical subjects

J Borowski

Publications and source records attributed to J Borowski.

At least 55 records · Page 3Linked to original sources
PubMed1983

Functional studies on mouse macrophages activated by phospholipids from Listeria monocytogenes and Aspergillus fumigatus.

The administration of phospholipids from Listeria monocytogenes and Aspergillus fumigatus to mice resulted in the development of macrophages with increased functional activity. It has been found that stimulated macrophages have increased phagocytic activity, enhanced chemotactic reactivity and augmented adherence to plastic surface. The activity of FcIg macrophages and complement receptors as well as the rate of the recovery of the FcIg receptors after phagocytosis were significantly higher in activated cells. The increase in phagocytosis, and FcIg and complement receptors activity was observed in macrophages cultured in vitro with phospholipids studied.

Animals↗
PubMed1981

The effect of bacterial and fungal phospholipids on immune response to sheep erythrocytes and E. coli lipopolysaccharide.

The effect of phospholipids extracted from some bacteria and fungi on the response of mice to sheep erythrocytes and E. coli lipopolysaccharide has been studied. The phospholipids from Staphylococcus aureus. Streptococcus faecalis, Bacillus subtilis and Aspergillus fumigatus augmented the humoral immune response to both antigens studied. The phospholipids from Asp. fumigatus, Str. faecalis and Candida albicans stimulated mouse B lymphocyte proliferation in vitro. On the other hand, none of the phospholipids studied could aid ovalbumin to induce delayed hypersensitivity in guinea pigs, and all phospholipids were not mitogenic for mouse T lymphocytes. Phospholipids from Cryptococcus neoformans and Penicillium notatum were without adjuvant activity, and those from C. albicans suppressed the response to sheep erythrocytes.

Adjuvants, Immunologic↗
PubMed1981

The effect of bacterial and fungal phospholipids on the activity of macrophages.

The effect of some bacterial and fungal phospholipids on the functions of macrophage in mice was studied. It has been found that in animals injected with phospholipids from Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis and Aspergillus fumigatus the population of macrophages with increased phagocytic and microbicidal activity appeared. The phospholipids from Cryptococcus neoformans and Penicillium notatum did not affect the activity of macrophages. Administration of the Candida albicans phospholipids to mice resulted in the decrease of the macrophage activity. These phospholipids exerted also toxic action on phagocytes in vitro. On the other hand phospholipids from Aspergillus fumigatus stimulated mouse macrophages in vitro.

Adjuvants, Immunologic↗
PubMed1980

Effect of Listeria monocytogenes lipids on the immunity of mice against Candida albicans, Cryptococcus neoformans and Trichomonas vaginalis.

The effect of Listeria monocytogenes lipids (Lm lipids) on immunity against Candida albicans, Cryptococcus neoformans and Trichomonas vaginalis was studied in mice. The administration of Lm lipids did not affect significantly the course of T. vaginalis infection. On the other hand, single Lm lipids injection markedly decreased the mortality rate of mice with mycotic infections, and significantly accelerated the elimination of fungal cells from liver, spleen and blood circulation of animals. It is suggested that enhanced resistance of mice conferred by Lm lipids may be related to observed increase in activity of macrophages. The study demonstrated a very low toxicity of Lm lipids preparation.

Animals↗
PubMed1980

The effect of Listeria monocytogenesis lipids on the mouse lymphocytes in vitro.

The effect of Listeria monocytogenes lipids (LML) on the incorporation of 3H-thymidine into mouse spleen lymphocytes cultured in vitro was studied. It has been found that LML was mitogenic for B lymphocytes but did not stimulate T lymphocytes. The presence of autologous T dependent cells did not change the intensity of B lymphocytes stimulation of LML. However, macrophages markedly increased the effect of LML on B lymphocytes. The supernatants of the cultures of unfractionated spleen lymphocytes stimulated with LML, contrary to those stimulated with PHA, did not inhibit the macrophage migration. It has been concluded that LML is an unspecific B lymphocyte mitogen.

Adjuvants, Immunologic↗