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Biomedical subjects

J Bouw

Publications and source records attributed to J Bouw.

31 records · Page 2Linked to original sources
PubMed1982

Canine intervertebral disc disease: a review of etiologic and predisposing factors.

In this report the literature on etiologic and predisposing factors of disc disease in the dog is reviewed and discussed. Hypochondroplasia is considered to be important in the etiology of disc disease. After some consideration on nomenclature and morphology, the genetic background of hypochondroplasia is described. The histochemical morphological and developmental similarities and differences between and within various dog breeds are discussed. Macroscopically visible features that predispose to disc disease are outlined. The biomechanical bow-string model of the vertebral column is reviewed. In the discussion the various literature data are interrelated to show how disc disease might be reduced by breeding measures without implicating the breed characteristics. Literature recommendations to help the individual dog are included.

Achondroplasia↗
PubMed1982

Hip dysplasia and dog breeding.

Hip dysplasia is considered to be one of the most serious problems in dog breeding. In the past 20 years the studies of, and the attempts to control, this condition have been directed mainly to the overall picture of the abnormality of the hips. The various efforts have resulted in a decrease in the incidence of HD in several breeds of dogs. For other breeds the results have not been very convincing, however. In some instances they are even said to be conflicting with other aims of breeding. Based on these data some separate studies have recently been performed in respect of the details of the disorders in the hip joints and of the heritability of these elements. The present study concerns itself with the roots of the disorders as they are observed in the various breeds. A great variety of data indicates that selection within the canine species for specific morphological traits must be considered as one of the most important roots of the occurrence of HD. The collected data strongly indicate that improvements in the HD status in the various breeds can be reached by selection against specific disorders of the hip joints in these breeds.

Animals↗
PubMed1981

Biochemical polymorphism in the rat: genetics of three electrophoretic variants and characterization of inbred strains.

Nine inbred strains of the rat (Rattus norvegicus) were screened for differences in electrophoretically detectable proteins. Interstrain variation was observed for 7 of 26 proteins. Three of these variants have not been described previously: leucine aminopeptidase (Lap-1), major urinary protein (Mup-1), and seminal vesicle protein (Svp-2). Genetic analysis revealed two autosomal alleles for each of these polymorphisms. The loci Lap=1, Mup-1, and Svp-2 are linked neither to one another nor to the previously described Svp-1 and Es-4 loci. Each of the nine strains can be identified now by a specific set of monogenic markers.

Animals↗
PubMed1979

[Dog breeding in the Netherlands (author's transl)].

The present report is a review of the history of dog breeding and of the current status of breeding dogs in the Netherlands. Breeds of dogs were previously subjected to methods of breeding in which survival and reproduction of the animals depended on the usefulness of dogs for various duties. Today, animals of these breeds are mainly kept as pets. Although serious breeders try hard to preserve the original characteristics of the animals, the breeds are nowadays subjected to strong forces of fashion and the pressure of public opinion. A marked increase in interest in special breeds is resulting in a reduction of the pressure of selection and thus in a wide variety of undesirable traits. In the opinion of the present author improvement of knowledge and in the understanding of dogs provides the best weapon to combat these unwanted effects.

Animals↗
PubMed1977

Serum esterase genetics in rabbits. IV. The prealbumin and beta-globulin systems.

Discontinuous starch gel electrophoresis revealed a fourth allele of rabbit pre-albumin serum esterase at locus Est-2. This allele is designated Est-2f and appears to be silent. In addition to the prealbumin serum esterases, another serum esterase system was studied in rabbits. This system is localized in the beta-globulin region. Genetic analysis indicated that one locus with two codominant alleles controls the variation in this region. Linkage of this system with Est-1 and Est-2 of the prealbumin serum esterases was demonstrated. Comparison of the arrangement of these esterase loci on linkage group VI with the esterase loci on chromosome 8 of the mouse gives additional support for the theory of evolutionary conservation of chromosomal segments coding for mammalian esterases.

Alleles↗
PubMed1977

Gene clusters in the blood group system B of cattle.

In this report the linear order of genetic determinants for the blood group system B of cattle has been worked out in more detail. Two groups of antigenic specificities--inclusion groups--showing serologic relationship are described. Recombination frequencies do suggest that these specificities are controlled by two clusters of genetic determinants. The structures of these inclusion groups and clusters are compared with those of antigenic complexes in other species, especially in mice. Several similarities and also dissimilarities between the blood group system B of cattle and the H-2 system in mice are described.

Animals↗