PubMed Health⌕ Search

Biomedical subjects

J Bras

Publications and source records attributed to J Bras.

At least 37 records · Page 2Linked to original sources
PubMed1992

Dermal angiosarcoma of the breast: a complication of primary radiotherapy?

A 70-year-old female developed recurrent disease following radiotherapy for primary inoperable breast cancer 5.5 years previously. Salvage mastectomy was performed. Pathology revealed recurrent breast cancer, along with a second primary malignancy, a dermal angiosarcoma. Radical excision of recurrent angiosarcoma failed. Irradiation combined with hyperthermia showed good palliation. The angiosarcoma's possible relation to the initial radiotherapy is discussed.

Aged↗
PubMed1992

Nutritional profiles of chronic alcoholics.

An epidemiological study of 58 variables from 300 chronic alcoholic and normal subjects was carried out in the Cardiology, Gastroenterology, Neurology, Psychiatry and Alcohology Departments in order to research, within this chronic alcoholic population, a correlation between diet, alcohol intake, tobacco use and the various alcohol-related diseases. A standardized questionnaire (previously tested) was used to relate dietary intakes (proteins, fats, carbohydrates, water and energy) to drinking and smoking habits. Discriminant analyses were used as appropriate. The alcoholic population is made up of subjects with strong oral-intake behaviour and can be classified in relation to their alcohol-related diseases. The alcoholics with cardiovascular and digestive diseases have the two (1st and 2nd) richest diets, respectively, consisting mainly of saturated fats and animal proteins, together with the lowest daily alcohol intake, the highest recorded total quantities of alcohol intake and the longest period of alcohol abuse before alcohol-related disease diagnosis. The 4th and 5th places can be reserved for the alcoholics with neurological and psychiatric diseases with opposite eating and drinking behaviours, i.e. with the poorest diet (less in terms of proteins and fats, although more than the normal population), the highest daily alcohol intake, the lowest quantities of total alcohol intake and the shortest time of alcohol abuse before disease diagnosis. The alcoholic population with subjects free of alcohol-related disease including mixed subjects, who either had not yet started or will never present any alcohol-related disease, occupy the intermediate place (3rd) in this classification.

Alcoholism↗
PubMed1991

Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma.

This paper describes the results of radiotherapy in early stage orbital non-Hodgkin's lymphoma. From 1970 to 1985, 33 orbital localizations in 30 patients were treated. The total dose applied ranged from 21 to 57 Gy (2 Gy per fraction), two-thirds of all patients received a dose of 40 Gy. The complete-response rate was 94% and the 10 years actuarial survival was 90%; no significant difference in survival was observed between patients with low grade or intermediate grade lymphoma. No local recurrence was detected during follow up and 20% of the patients developed generalized disease. Two optic nerve neuropathies and three retinopathies were observed in five patients, four of these occurred at a dose level of less than 43 Gy. Keratitis occurred in 58% of the patients treated, a sicca syndrome in 30% and cataract of different grades in 58% of the patients treated. Although local control was excellent, severe complications were observed in 13% of the patients who received a dose of less than 43 Gy.

Dose-Response Relationship, Radiation↗
PubMed1991

Intradiploic epidermoid cysts of the bony orbit.

Epidermoid cysts originating within the diploic space of the bony orbit are rare. The authors retrospectively studied four patients with an intradiploic epidermoid cyst of the orbital bones to investigate the clinical and the computed tomographic (CT) findings. The clinical presentation was dependent on the location of the slowly expanding epidermoid cyst. The sphenoid bone was involved in three patients and the frontal bone in one patient. Proptosis caused by intraorbital extension of the mass was the most common presenting sign. The findings on high-resolution CT scans appeared to be specific for intradiploic epidermoid cysts. The typical sclerotic margin, which is diagnostic of intradiploic epidermoid cysts, can be demonstrated by CT scans with a bone window setting.

Adolescent↗
PubMed1991

Leiomyosarcoma of large and small veins: clinical findings and results of treatment in six patients.

Vascular leiomyosarcomas are rare malignant tumours originating from the media of the vessel wall. Six patients (five women and one man, aged 44-66 years) have been treated for a vascular leiomyosarcoma located in the inferior vena cava (three patients), the suprarenal, the external iliac and an antecubital vein. In four patients, the tumour was large and extended beyond the vessel wall giving rise to a retroperitoneal mass. In two patients the tumour was confined to the inner wall of respectively a large and small vein, occluding the lumen; the former was in the inferior vena cava and the latter in an antecubital vein. Block resection was performed in all patients. The tumours showed mitotic indices ranging from 6-32 mitoses/10 high power fields. The five patients with retroperitoneal tumours received additional radiotherapy varying from 50.00-70.00 Gy, on the basis of either macroscopic residual tumour or indefinite radicality. One of these five patients developed distant metastases within 2.5 years without local recurrence, the other four had no evidence of recurrence at follow-up, 3-7 years (mean 4.2 years) after surgery. The results illustrate the role of adjuvant radiotherapy in the control of local recurrence, when resection in this type of tumour proves to be either non-radical or totally radical.

Adult↗
PubMed1990

Diffuse sclerosing osteomyelitis of the mandible: a new concept of its etiology.

Diffuse sclerosing osteomyelitis of the mandible is a disease of unknown etiology. The clinical and radiographic findings suggest an infectious origin, but bacteriologic and histologic findings do not support this concept. Analysis of clinical symptoms, localization of the condition, and posttreatment findings in a group of 27 patients suggest a chronic tendoperiostitis due to muscular overuse as an etiologic factor in diffuse sclerosing osteomyelitis of the mandible. This hypothesis was supported by the initial results of muscle relaxation treatment in 13 of these patients.

Adolescent↗
PubMed1990

Oral manifestations of non-Hodgkin's lymphoma in HIV-infected patients.

The incidence of non-Hodgkin's lymphomas (NHL) in patients infected with human immunodeficiency virus (HIV) is relatively high. However, there have been few reports on the clinical and histopathological features of oral manifestations of NHL in these patients. The lesions reported so far were all tumorous swellings with or without ulceration, as in non-HIV-infected patients. In this report 3 cases are presented of HIV-infected patients with solitary, primary oral NHL. These lesions showed a striking resemblance to acute, necrotizing gingivitis, a common finding in these patients, thus making the diagnosis more difficult.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Assessment of creatinine clearance in intensive care patients.

Assessment of creatinine clearance (CC) in ICU patients was compared using three methods. The reference method (CC 24 h) used measurements of serum creatinine and urinary creatinine after collection of urine over a 24-h period. The other two methods were predictive methods: the Kampmann nomogram and the formula developed by Gault and Cockcroft. The two predictive methods correlated well with one another. Correlation between the predictive and the reference methods was poor or absent. A discriminant analysis revealed that measurement of urinary creatinine was a major factor in CC estimation. In conclusion, the reference method of CC assessment is preferred to obtain a reliable estimation of glomerular filtration rate in ICU patients.

Adolescent↗
PubMed1990

[Mandibular atrophy and metabolic bone loss].

Radiological studies in edentulous patients with and without atrophy of the mandible and radiological, histomorphometrical and endocrinological studies in edentulous patients with a severe atrophy of the mandible and treated by ridge augmentation has shown that: metabolic bone loss, histologically and endocrinologically characterized as a secondary hyperfunction of the parathyroid glands, is a causal factor in the pathogenesis of mandibular atrophy.

Aged↗
PubMed1990

Mandibular atrophy and metabolic bone loss.

Radiological studies were performed on edentulous patients with and without atrophy of the mandible. Radiological, histomorphometrical and endocrinological studies were performed in edentulous patients with a severe atrophy of the mandible treated by ridge augmentation. The results of these studies showed that metabolic bone loss, histologically and endocrinologically characterized as a secondary hyperfunction of the parathyroid glands, is a causal factor in the pathogenesis of mandibular atrophy.

Adolescent↗
PubMed1988

Diffuse sclerosing osteomyelitis of the mandible: clinical radiographic and histologic findings in twenty-seven patients.

Diffuse sclerosing osteomyelitis of the mandible is a disease of obscure origin that may give rise to diagnostic problems. In the literature most authors suggest an infectious etiology. However, the results of treatment are generally poor. Clinical and radiographic findings in this study of 27 patients suggested an infectious origin of the disease. However, bacteriologic findings in 11 of these cases did not support this suggestion. The histologic findings showed a reactive hyperplasia of bone. The results of treatment, based on the assumption of an infectious etiology, were poor. It was concluded that the findings in this group of patients did not support an infectious etiology of the disease.

Adolescent↗
PubMed1988

Mandibular atrophy and metabolic bone loss. Histomorphometry of iliac crest biopsies in 74 patients.

Histomorphometry of iliac crest biopsies of 74 edentulous patients with severe atrophy of the mandible submitted for ridge augmentation, showed a minority of the patients (14%) to have a significant decrease of trabecular bone volume, indicating osteoporosis. On the other hand, osteoid volume, osteoid seam thickness and active resorption surface, parameters for disturbances in mineralization, lack of calcium and hyperfunction of parathyroid glands, were significantly increased by 38%, 88% and 65% of the patients, respectively. These findings were more pronounced in the patients with radiological evidence of metabolic bone loss (38%, Gonion less than 1). It may be concluded that metabolic bone loss, due to a lack of calcium and a subsequent hyperfunction of the parathyroid glands, plays a role in the etiology of severe atrophy of the edentulous mandible. which therefore might be prevented by supplementing with calcium with or without vitamin D.

Adult↗
PubMed1988

Mandibular atrophy and metabolic bone loss. Endocrinology, radiology and histomorphometry.

In 11 edentulous patients with a severe atrophy of the mandible and submitted for ridge augmentation, endocrinological, radiological and histomorphometrical studies were carried out. The results showed that metabolic bone loss, histologically in nearly all patients characterized as a disturbance in mineralization and endocrinologically in 55-73% of the patients as a secondary hyperfunction of the parathyroid glands, plays a rôle in the etiology of mandibular atrophy.

Atrophy↗
PubMed1988

[Reduction of the alveolar ridge: causes, sequelae and prevention].

The alveolar ridge (of upper and lower jaw) serves as a supporting tissue for the teeth. This function disappears after natural dentition has been extracted. Even so, the alveolar ridge remains very important, serving as it does to support and give retention to dentures. However, after removal of the natural dentition alveolar ridge reduction occurs, initially at a fairly rapid rate, slowing down later, but in an ever-continuing process, which, particularly in the long run, may have unpleasant consequences. As many factors may affect this reduction process unfavourably, it is very difficult to take one specific preventive measure. The most effective way of preventing alveolar ridge reduction is obviously the prevention of any edentulous condition, which unfortunately is not always possible. Nowadays a frequently used treatment of which a great deal is expected, is the application of the so-called overdenture. Further research is needed, however, for a proper evaluation of its long-term favourable effects on alveolar ridge reduction.

Aged↗
PubMed1987

Rhabdomyosarcoma of the oral soft tissues.

Between 1944 and 1984 16 patients with rhabdomyosarcoma of the oral soft tissues were treated at the M.D. Anderson Hospital and Tumor Institute. Before 1968 treatment consisted only of surgery. Chemotherapy and radiotherapy were used when surgery was impossible or in an effort to treat recurrent disease. After 1968 treatment design was multidisciplinary and included (excision) biopsy, followed by a combination of high-dose radiotherapy and multidrug chemotherapy. Of the six patients treated before 1968, five (83%) died of disease. In eight of the ten patients treated after 1968, follow-up was 4 years or more. Of these eight patients, seven (87.5%) are free of disease. The clinicopathologic aspects, treatment, complications of treatment, and survival figures are discussed.

Adolescent↗