Biomedical subjects
Publications and source records attributed to J C Angulo.
A case of renal adenocarcinoma arising in a 18 year-old boy is reported. This is a rare entity in childhood and adolescence that displays a similar histology to the adult form. The recent literature on its clinical and pathological features is reviewed. We conclude that, despite its rarity, adenocarcinomas must be included in the differential diagnosis of solid renal masses in early life.
We report a complicated case of renovascular hypertension from bilateral atherosclerotic renal artery stenosis in a solitary functioning kidney. Percutaneous transluminal angioplasty (PTA) was performed after diagnostic arteriography. Hypertension remitted only after surgical removal of the nonfunctioning kidney. In our view, PTA is the procedure of choice even in the solitary kidney.
We present a case of urinary bladder carcinoma in a child aged 13 that followed a benign course. This confirms the idea that epithelial bladder cancer in children pursues, a much less aggressive behaviour than in the adult, possibly on the basis of its well-differentiated nature. Despite the rarity of the lesion, it should not be overlooked in the differential diagnosis of haematuria in children.
The microscopic anatomy of the oesophago-gastric territory is interpreted as the result of the interaction of three main phenotypes: squamous, oxyntic and intestinal. This synthesis allows the comparison between phenotype development, atrophy and metaplasia. The concomitances in the processes of development and repair lead to the proposal of an intestinalization gradient inherent to the oesophago-gastric field. This hypothesis permits an integration of the epithelial changes associated with gastritis and oesophagitis together with ontogenesis. The global tendencies in epithelial development and repair are discussed; a link between the two appears evident. The shifting potential of the progenitor gland zones in development and repair is in consonance with Wolpert's theory of positional information.
We intend to approach the genitourinary and nephrological pathologies presented in our environment by patients with HIV infection. To this end we have carried out a retrospective study on a series of patients selected on the basis of follow-up possibility. A continuous history, recording a detailed clinical examination including repeated sampling and serological testing, would allow us to stress the relevance of hidden urological pathologies which these patients rarely complain about. Further studies with larger series are required to be able to establish a relationship between nephro-urological symptoms and the disease evolution parameters.
The paper describes an unusual angiographic pattern within the context of stenosis of the pyeloureteral union and giant hydronephrosis of the adult, with a presumed congenital origin. From the embryonic point of view we discuss the remote possibility of this being a real "agenesis" of the renal artery with no agenesis of the kidney, irrigated by multiple segmental arteries following the characteristic metamerism of the mesonephros. On the other hand, it seems more consistent to explain such vascular pattern as an image of severe atrophy, in correlation with the hydronephrosis advanced stage, and not as a primary congenital defect. However, the interaction of both factors (congenital-malformative and acquired-involutive) could be more overlapped than what initially appears to be.