Biomedical subjects
Publications and source records attributed to J C Briggs.
A Melanoma Register, previously organised on a filing card system, has been largely transferred to a computer which utilises both word and data processing programs. This transfer has revolutionised not only the analytical potential of the material, but the follow up of all patients, both old and new. The system is applicable to many other tumours and diseases.
3 cases of primary oral malignant melanoma are described. 2 of these patients died as a result of metastatic disease, one 12 months after the initial diagnosis, the other within 33 months. The 3rd patient, still alive after 27 months, has metastatic melanoma deposits in the liver. The clinical presentation of oral malignant melanoma is discussed and reference is made to treatment and the overall prognosis of the lesion.
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A review of 955 patients with primary oesophageal carcinoma treated with this hospital revealed 23 cases of small cell anaplastic carcinoma of the oat cell type. Fifteen were females and eight were males. In each case the histological appearances were identical to those of the oat cell carcinoma which is much more commonly encountered in the lung. In none of these cases was there any evidence of a primary oat cell carcinoma outside the oesophagus. Argyrophilic granules were seen in three cases and granules of the neurosecretory type were present in five. We conclude that neither of these findings is a prerequisite for making a diagnosis of oesophageal oat cell carcinoma. The histogenesis of this tumour is reviewed and briefly discussed.
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Some of the facilities available with a commercially purchased word processing program, linked to a DEC PDP 11/23 computer are described, together with an account of the practical histopathological use. The system is based on a share of the computer with a Clinical Chemistry Department. Development was time-consuming and required the constant availability of the Department of Physics. However, once working, considerable saving in secretarial time has resulted and a number of projects have been started which would not have been contemplated without the use of the word processor and its linked computer.
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Reticulin patterns were examined in 25 consecutive malignant melanomas, 25 benign cellular naevi and 10 Spitz (benign juvenile) naevi. Absolute features were that a completely intact basement membrane was a strong indicator of benignity and that pericellular reticulin was evidence of subsequent benign behaviour. In routine circumstances however, the stain was of little diagnostic use, as the borderline cases on haematoxylin and eosin staining were not made any easier to categorize by reticulin stain.
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