Desmoplastic Melanoma (DM) represents a rare histological variant of melanoma. It has been described in isolated case reports as a cutaneous tumour with a high incidence of local recurrence and nodal metastases, requiring early aggressive surgery. However, overall clinical experience of the tumour is limited. 13 patients with DMM seen over a 20 year period were reviewed. The mean age at presentation was 67 years (range 34-87), and 2/3 of the lesions were in the head and neck. Tumour thickness averaged 5.78 mm (Breslow). 7 patients developed recurrence, 4 as regional nodes, and 3 as skin nodules. Four of these patients developed disseminated disease, of whom 3 died. The mean time to first recurrence was 26 months and mean follow-up time in the review was 40 months (range 3-141 months).

Adult↗

PubMedDate not supplied

Subungual melanoma: a clinico-pathological study of 24 cases.

Twenty-four patients with subungual melanoma (13 women and 11 men) had a mean age of 61.6 years. Twenty-two lesions arose either on the thumb or hallux. The mean delay before diagnosis was 30 months. Two patients presented with stage two melanoma and three of the melanomas were in situ lesions (Clark level 1). Nineteen melanomas were Clark level 4 or 5 and the mean thickness of the invasive melanomas was 4.7 mm. Seven patients died of metastatic disease (mean survival 10 months, range 6-50 months). Clark level, thickness and mitotic activity of the melanomas correlated with poor clinical outcome. Delay in presentation and the presence of advanced disease contribute to the poor prognosis of this tumour.

Adolescent↗