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Biomedical subjects

J C Gardner

Publications and source records attributed to J C Gardner.

10 recordsLinked to original sources
PubMed1990

Haemonetics V50 and Plasma Collection System: common concerns and troubleshooting.

The Haemonetics V50 and PCS are automated centrifugal systems designed for the collection of a variety of apheresis products. The microprocessor-controlled systems increase collection efficiency through many safety features and high donor and operator appeal. Troubleshooting the systems has been simplified through a systematic approach and easily understood display messages.

Blood Component Removal↗
PubMed1988

Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively.

cDNAs encoding human proteins C and S have been used to screen a panel of mouse-human somatic cell hybrids to determine the chromosomal location of their respective genes. The gene for human protein C is located on chromosome 2, whereas that for protein S is located on chromosome 3. Analysis of human genomic DNA restriction endonuclease fragmentation patterns suggests that the human protein S gene is greater than 40 kb in size and contains a minimum of 11 introns.

Animals↗
PubMed1987

Mechanisms for binocular depth sensitivity along the vertical meridian of the visual field.

By removing the visual cortex unilaterally, and recording along the intact 17/18 border, we have investigated the influence of the corpus callosum on the tuning curves for stimulus disparity of cat cortical neurons. Responses to binocular stimulation were examined to movement in the same (in-phase) and in the opposite direction (antiphase) across the two retinae. In lesioned cats, as in normal cats, units were encountered which showed high sensitivity and narrow tuning for stimulus disparity. In contrast to normal cats, however, lesioned cats showed a reduced proportion of units displaying moderate binocular interactions, as well as a substantial increase in disparity-insensitive cells. The loss of disparity sensitivity after decortication was associated with a reduced incidence of both selectivity for the direction of stimulus motion and binocular activation. No large differences between the preparations were seen, however, in the ocular dominance of the total populations of cells. Differences between the normal and lesioned cats were found in binocular responses to in-phase but not to antiphase stimulation motion. Tuning curves in lesioned cats showed reduced binocular inhibition but no changes in binocular facilitation. Our findings indicate that callosal input contributes to unit disparity sensitivity by enhancing direction-selective binocular inhibition. The corpus callosum generates disparity sensitivity in a population of units in the superficial cortical layers which may play a particular role in the perception of stereoscopic depth.

Animals↗
PubMed1986

Localization of human SAA gene(s) to chromosome 11 and detection of DNA polymorphisms.

A human serum amyloid A (SAA) cDNA was used as a probe in chromosome mapping studies to detect human SAA gene sequences in DNA isolated from human/mouse somatic cell hybrids. Southern analysis of DNA from 20 hybrid cell lines, including some with translocations of human chromosomes, placed the SAA gene(s) in the p11----pter region of chromosome 11. Screening of human DNA from unrelated individuals by Southern analysis using the SAA cDNA probe revealed restriction fragment polymorphisms for HindIII and PstI. An analysis of the segregation of these polymorphisms with other markers on the short arm of chromosome 11 should more precisely map the SAA gene(s).

Amyloid↗
PubMed1986

Ocular dominance and disparity-sensitivity: why there are cells in the visual cortex driven unequally by the two eyes.

Tuning curves for stimulus disparity were constructed for units in area 18 and along the 17/18 border of the cat visual cortex (N = 248). Units were activated with stimuli moving in the same (in-phase motion) or in the opposite direction (antiphase motion) across the two retinae. Over 70% of the units encountered showed sensitivity to stimulus disparity. A clear relationship was found between disparity-sensitivity and unit ocular dominance (OD). Contrary to what might have been expected, large binocular interactions were correlated with unilateral OD. Units highly sensitive to stimulus disparity generally showed strong dominance by one eye (OD groups 1, 2, 6 and 7), or responded well only to binocular stimulation, and weakly or not at all through each eye separately ("binocular-only"). Units unselective for stimulus disparity were usually driven well through either eye (OD groups 3, 4 and 5). High disparity-sensitivity was due to both strong binocular inhibition and strong binocular facilitation in units of extreme unilateral OD. Nearly all units of OD groups 1 and 7 showed clear binocular interactions, indicating that there are few "truly monocular" cells in the cat visual cortex.

Animals↗
PubMed1978

The Lewin Report.

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Legislation, Nursing↗