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J D Hsu

Publications and source records attributed to J D Hsu.

57 records · Page 4Linked to original sources
PubMedDate not supplied

Idiopathic scoliosis: a clinical, morphometric, and histopathological correlation.

At the time of spinal fusion, muscle biopsies were taken from both the convex and concave side at the apex of the curve from 27 patients with idiopathic scoliosis. Histochemical and morphometric studies showed generally small and atrophic type 1 muscle fibers on both sides, with preservation of the normal type 1 predominance. The most striking abnormality was a type 2A predominance over type 2B fibers, the reverse of normal in the paraspinous muscle. These changes showed no correlation with sex, age, or electrical stimulation but showed a significantly greater severity with the duration and severity of the curve. We conclude that these changes are a secondary muscle adaptation to the curve and not its primary etiology.

Adolescent↗
PubMedDate not supplied

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by geniposide.

The effects of topical application of geniposide on 12-o-tetradecanoylphorbol-13-acetate(TPA)-induced promotion of skin tumors, hyperplasia, ornithine decarboxylase (ODC) and inflammation were evaluated in female CD-1 mice. Topical application of geniposide (0.2 to 1.0 mumol) with TPA (15 nmol) twice weekly for 20 weeks to mice previously initiated with benzo[a]pyrene (B[a]P) inhibited the number of TPA-induced tumor per mouse by 84 or 89%, respectively. Pre-application of the same amount of geniposide also afforded significant protection against TPA-induced hyperplasia in the ear skin. Topical application of geniposide inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol). The topical application of geniposide (0.2 or 1.0 mumol) inhibited TPA-induced edema of mouse ears by 41 or 43%, respectively. Pretreatment of mouse skin with various amounts of geniposide caused inhibition of hydrogen peroxide (H2O2) and myeloperoxidase (MPO) formation by TPA. These results indicate that geniposide possesses potential as a cancer chemopreventive agent against tumor promotion.

Animals↗