PubMed Health⌕ Search

Biomedical subjects

J Demeter

Publications and source records attributed to J Demeter.

85 records · Page 5Linked to original sources
PubMed1976

Comparative study of the effect of ethyl apovincaminate and xantinol nicotinate in cerebrovascular diseases. Immediate drug effects on the concentrations of carbohydrate metabolites and electrolytes in blood and CSF.

Randomly selected 34 cerebrovascular patients were treated with ethyl apovincaminate (RGH-4405, Cavinton) and 109 with xanitinol nicotinate. The effects of drugs given in slow i.v. infusions on the concentration of carbohydrate metabolites and electrolytes in serum and CSF were observed. Cavinton improved the paresis in 60.6% of patients while xantinol nicotinate did so only in 47.1%. On the basis of the biochemical changes it can be concluded that Cavinton enhances both the glycolytic and the oxidative glucose breakdown in CNS.

Brain↗
PubMedDate not supplied

Autoantibody occurrence in hairy cell leukemia.

BACKGROUND: Autoimmune syndromes accompanying hairy cell leukemia (HCL) may represent a specific entity in HCL patients. It has been claimed that interferon (IFN)-alpha therapy contributes to the occurrence of autoantibodies in HCL. The study was undertaken to determine the occurrence of autoantibodies in HCL patients prior to IFN-alpha therapy. PATIENTS AND METHODS: Sera of 24 patients with HCL of B-cell origin (as determined previously by peripheral blood mononuclear cell surface markers and/or DNA rearrangement studies) were investigated. In addition serum from a T-HCL patient was studied. Nineteen of the 25 HCL patients had been splenectomized prior to the study. One patient was found to have IgM lambda monoclonal protein in her serum. Antinuclear antibodies were determined with an indirect IF test using Hep-2 cells. Rheumatoid factors of the IgM and IgA classes were determined by enzyme-linked immunosorbent assay (ELISA). Granulocyte-specific antinuclear antibodies and antineutrophil cytoplasmic antibodies were determined by indirect immunofluorescence. RESULTS: No clinical syndrome of an autoimmune disease was apparent in any of our HCL-patients. Rheumatoid factors of either IgM or IgA class were found in the sera of six B-HCL patients and antinuclear antibodies in five cases, while anti-cytoplasmic antibodies were identified in only three cases. The occurrence of antibodies seemed to be independent of the clinical stage of the disease as determined according to the functional criteria. Two patients with arthralgias and one with vitiligo had no autoantibodies in their sera. CONCLUSIONS: Autoantibodies might occur in HCL patients prior to treatment with interferon-alpha and in the absence of the clinical syndrome of an autoimmune disease.

Adult↗