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Biomedical subjects

J Docherty

Publications and source records attributed to J Docherty.

13 recordsLinked to original sources
PubMed1992

Total quality management within the NHS.

Total quality management is a system which enables managers to analyse and develop their services within a common framework. It incorporates the needs and preferences of service users in the setting and improvement of quality standards, within resource constraints.

Humans↗
PubMed1987

Ageing and alpha 1 adrenoceptors in the iris.

This study was undertaken to determine if the age related decrease in pupil size is attributable to altered sympathetic adrenoceptor responsiveness. Log dose response curves using the selective alpha 1 agonist phenylephrine and antagonist thymoxamine showed that there is no difference in alpha 1 adrenoceptor sensitivity in the elderly and the young. Therefore age related miosis is not caused by an alteration in alpha 1 receptors with age.

Adult↗
PubMed1976

The use of 5-(125I)iodo-2'-deoxyuridine for monitoring DNA synthesis in organ culture.

5-[125I]iodo-2'-deoxyuridine (125IUdR) has been shown to be effective in monitoring DNA synthesis in murine tumour and human benign prostatic hyperplasia explants maintained in organ culture for 2 days, thus making possible the rapid screening of antitumour drugs. Uptake was linear for at least 24 hours in the case of the murine tumour and for 6 hours in the case of the prostate. Hydroxyurea almost completely blocked uptake by the murine tumour at doses above 10(-4) mole. Fluorodeoxyuridine (10(-6) mole) markedly increased the uptake of 125IUdR into the human prostate explants. Fixation of the murine tumour explants in alcoholic Bouin after culture did not alter the radioactive uptake and so routine histological examination of the tissue can be carried out after counting, which is a major advantage over [3H]thymidine.

Adenocarcinoma↗