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Biomedical subjects

J E Josephson

Publications and source records attributed to J E Josephson.

At least 19 recordsLinked to original sources
PubMed1992

Corneal staining characteristics after sequential instillations of fluorescein.

Twenty-one healthy noncontact lens-wearing subjects were screened for the presence of corneal staining with fluorescein after sequential instillations of the vital stain (Phase I). These staining characteristics were further explored by monitoring the results of sequential instillations of fluorescein at 2-h intervals over a 12-h period (Phase II) and by patching 1 eye overnight and observing corneal staining after sequential instillations of fluorescein in the morning after patch removal (Phase III). In Phase II more eyes stained in the early morning. Throughout the day the most common staining areas were inferior and nasal. In Phase III, 9 of 12 patched eyes presented with fluorescein staining, as did 7 of the 12 unpatched eyes. Corneal staining after sequential instillations of fluorescein is more likely to be observed early in the day and is not reduced by overnight patching.

Adolescent↗
PubMed1991

Contact lens considerations in surface and subsurface aqueous environments.

Contact lenses can be a practical and visually efficient corrective modality in aqueous surface and subsurface environments. Even though contact lenses have many advantages for the ametropic individual, in certain situations there may also be disadvantages such as the risk of lens loss, ocular injury, or infection. In order to be able to wear contact lenses in these environments both prescribing practitioners and contact lens wearers must know when the risks of contact lens wear in these environments are minimal. In addition, they must know what precautions to take to minimize risks.

Contact Lenses↗
PubMed1991

Corneal staining after sequential instillations of fluorescein over 30 days.

The corneal staining patterns of 6 healthy female subjects were monitored Monday through Friday for 4 consecutive weeks using daily sequential instillations of fluorescein. The patterns showed that in these subjects there was no predictable pattern of staining, that each subject had different staining characteristics, and that corneal staining varied day to day.

Cornea↗
PubMed1990

Monovision.

Monovision has been a controversial contact lens correction modality for over 30 years. This paper addresses the major issues and concerns and considers them in the light of patient safety, visual efficiency and practitioner liability.

Adaptation, Ocular↗
PubMed1990

Is there a better "comfort drop"?

45 hydrogel lens-wearing patients with healthy eyes and symptoms of dryness when wearing their lenses were asked to compare the effect of 10 different drops to reduce their symptoms of dryness. The drops were used in a random and blind fashion. Although there were great variations in individual responses, as a group these subjects preferred nonpreserved drops to reduce their symptoms of dryness.

Adolescent↗
PubMed1989

Clinical experience with the Tangent Streak RGP bifocal contact lens.

Eighty-one screened presbyopic subjects were fitted with the Tangent Streak Bifocal (TSB) rigid gas permeable contact lens. Sixty subjects received lenses, and of this group, 42 (70%) have worn the lens successfully for 6 months or longer. Failures mainly resulted from discomfort and occasionally, reduced visual quality. Successful subjects were particularly pleased with their crisp vision at distance and near. The TSB may be the lens of choice for those presbyopic patients who require high definition visual quality at distance and near.

Adult↗
PubMed1989

Investigation of the Alges bifocal.

A prospective study was undertaken to evaluate the success rate in fitting the Alges bifocal contact lens, and to determine which subject characteristics were associated with success. Fifty-eight presbyopic subjects with healthy eyes were included in the study. Thirteen subjects (22.4%) were screened out and discontinued after the fitting examination because of visual problems. Lenses were dispensed to 45 subjects (the dispensed group). Thirteen of these subjects were discontinued. Thirty-two subjects (71.1%) were considered successful after wearing their optimum lenses for 1 month. The successful group was interviewed by telephone after 3 months of wear. Two of these subjects were actually a "qualified" success. After 9 months, the successful group was again interviewed by telephone. Twenty-four subjects of the dispensed group were still considered to be optimally successful, five subjects were considered to be a "qualified" success and three subjects had discontinued lens wear. Our success rate for screened patients after 9 months was 64.4%. Two subject characteristics that were associated with success were a previous history of contact lens wear (p = 0.0065) and a near-point stereoacuity better than 100 s of arc with the Alges lens (p = 0.01).

Adult↗
PubMed1988

Corneal staining after instillation of topical anesthetic (SSII).

The ocular surface of 74 subjects was assessed with the biomicroscope after sequential instillations of fluorescein (SSI) and again after a single instillation of Ophthetic that was followed by sequential instillations of fluorescein (SSII). Twenty-six eyes (17.6%) stained after SSI and 89 eyes (60%) stained after SSII. The use of Ophthetic seems to enhance the nonuniform penetration of fluorescein into the epithelium in specific regions of the cornea of some subjects. The clinical significance of this finding is unknown.

Adult↗
PubMed1988

Ocular side effects of isotretinoin therapy.

Isotretinoin (Accutane Capsules) is a synthetic vitamin A compound used for treatment of recalcitrant cystic acne. It has numerous ocular toxic side effects which include anterior segment inflammation, dry eye syndrome, contact lens intolerance, altered refraction, photosensitivity, and reduced night vision. Eye care practitioners should be aware of these potential side effects and be prepared to communicate with the prescribing physician if side effects present.

Anterior Eye Segment↗
PubMed1988

Differentiation of corneal complications observed in contact lens wearers.

Corneal epithelial cystic formations and epithelial infiltrates are relatively common in contact lens patients. Accurate diagnosis of these conditions is needed for proper management of the patient, but the observation and differential diagnosis is hampered by the minute size and similar biomicroscopic appearance of these conditions. This paper presents a description of these subtle formations and the slit lamp techniques for differentiating epithelial microcysts, vacuoles, bullae, and infiltrates. The clinical significance of these conditions is also discussed.

Contact Lenses↗
PubMed1988

The dangers of distilled water in contact lens maintenance.

The reports of serious corneal infection associated with hydrogel lens wear prompted us to explore the level of sterility of the distilled water used by lens wearers in our practice. Fifty patients supplied samples of their partially-used distilled water for testing. Of the samples, 12% were found to be contaminated. Five samples of previously unopened distilled water were tested and no growth was found. We recommend that patients do not use distilled water for the care of hydrogel contact lenses. Rather, sterile unit dose or multi-dose (aerosol) nonpreserved, or preserved salines can be used.

Bacteria↗