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Biomedical subjects

J E Ogbuokiri

Publications and source records attributed to J E Ogbuokiri.

8 recordsLinked to original sources
PubMed1993

Ivermectin levels in human breastmilk.

Ivermectin levels were measured in breastmilk and plasma of 4 healthy mothers after an oral 150 micrograms/kg dose. Mean +/- S.D. plasma and milk values were 37.9 +/- 0.54 and 14.13 +/- 0.43 (ng/ml) respectively. Steady-state ivermectin levels in milk were low. Our results suggest that exclusion of lactating mothers from mass chemotherapy with ivermectin may be unnecessary.

Adult↗
PubMed1993

Protein binding and ivermectin estimations in patients with onchocerciasis.

We measured ivermectin in plasma, urine, and saliva of nine patients with onchocerciasis. The aim was to establish pharmacokinetic parameters and to assess the most facile medium for use in monitoring compliance. Binding of ivermectin to plasma proteins in vitro was also investigated. The mean (+/- SEM) plasma values for the nine subjects were as follows: weight, 66.3 +/- 2.8 kg; dose, 11.11 +/- 0.4 mg; half-life, 56.50 +/- 7.01 hours; clearance, 142.5 +/- 22.6 L/kg; volume of distribution, 9.91 +/- 2.67 L/kg; area under the plasma concentration-time curve, 1545.3 +/- 190.5 ng/ml.hr; time to reach maximum concentration, 4.7 +/- 0.5 hours; and maximum concentration, 38.2 +/- 5.8 ng/ml. Ivermectin was not detected in the urine of any of the nine subjects. Low levels were found in saliva. Blood specimens remain the only reliable biologic fluid for assessment of compliance after ivermectin oral administration. Ivermectin binds specifically to human serum albumin.

Administration, Oral↗
PubMed1990

Ivermectin binds avidly to plasma proteins.

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

Blood Proteins↗
PubMed1980

Self-monitoring of blood pressures in hypertensive subjects and its effects on patient compliance.

This study investigated the effects, if any, that teaching hypertensive patients to take their own blood pressures, as well as education and counseling, would have on compliance. Prior to the initiation of the study, the pharmacist-investigator collected data on the hypertension clinic as it traditionally functioned. This preliminary investigation included studying the work flow of the clinic and reviewing medical records to determine who among the clinic registrants met the criteria set up for inclusion in this study. During the study phase, 12 patients were educated about their disease state, counseled, and taught to take their own blood pressures, using a home blood pressure measuring device. Upon each return visit, they were evaluated by the pharmacist using such parameters as pill counts, blood pressure readings, fluctuations in body weight, and disease symptomatology. All these data were analyzed and compared to those of the 12 patients in the control group who were educated and counseled, but not taught to take their blood pressures. An overall improvement in any or all of these monitored parameters was the criterion for determining effectiveness in promoting better compliance. At the end of the five-month study, the frequency of prescription refill had increased from 38 to 72.56 percent for the treatment group and from 31.6 to 59.26 percent for the control group. There were no significant changes in the other parameters monitored during this period.

Activities of Daily Living↗
PubMedDate not supplied

Plasma levels of chloroquine in healthy Nigerian children: clinical and toxicological implications.

1. Sixteen healthy children attending the Well Baby Clinic of the University of Nigeria Teaching Hospital, Enugu were studied. 2. Upon obtaining a medication history that was negative for chloroquine over a three week period, a single random sample of venous blood was taken from each child for chloroquine analysis. 3. Analysis of plasma for chloroquine was done using an h.p.l.c. method. 4. Plasma levels of chloroquine in the children ranged from 77.8-224.7 ng/ml with a mean of 156.5 +/- 67.8 s.d. 5. In view of the danger of acute toxicity as well as the long-term effects, further studies are needed to determine the harmful effects such perennial presence of chloroquine, albeit in low levels, may have on our children.

Child Health Services↗