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PubMed · 2095348

Ivermectin binds avidly to plasma proteins.

U Klotz·J E Ogbuokiri·P O Okonkwo
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Abstract

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

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Blood ProteinsChromatography, High Pressure LiquidHumansIvermectinProtein BindingJournal ArticleResearch Support, Non-U.S. Gov't

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U Klotz, J E Ogbuokiri, P O Okonkwo. 1990. Ivermectin binds avidly to plasma proteins.. https://doi.org/10.1007/bf00316107

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