PubMed Health⌕ Search

Biomedical subjects

J F Annegers

Publications and source records attributed to J F Annegers.

At least 127 records · Page 7Linked to original sources
PubMed1982

Rheumatic fever in Rochester, Minnesota, 1935-1978.

The incidence of rheumatic fever in the population of Rochester, Minnesota, during the years 1935 through 1978 was determined by means of the medical records-linkage system of the Rochester Epidemiology Program Project. The annual age-adjusted incidence rate per 100,000 population for all episodes of rheumatic fever was 9.7, comprising 7.0 for initial attacks and 2.7 for recurrent attacks. There was a marked decline over time: incidence rates of initial episodes decreased from 13.6 in 1935-1949 to 8.2 in 1950-1964 and 2.7 in 1965-1978; and rates of recurrent attacks decreased even more--from 7.0 to 3.2 and 0.3 in the same intervals. There was also a secular trend in the clinical manifestations of rheumatic fever, as the proportion of initial episodes with carditis increased from 23% in 1935-44 to 52% in 1965-1978.

Adolescent↗
PubMed1981

Patterns of other neoplasia in patients with endometrial carcinoma.

A cohort of 1192 patients with endometrial carcinoma were followed up to determine the frequency of other malignancies among them. The incidence rate of all types of cancer was not greater than in the general population. The relative risk of breast cancer after endometrial carcinoma was 1.3 times population rates. This increase, however, was confined to those who shared risk factors common to breast cancer--that is, nulliparity and, to a lesser extent, obesity. The parous, nonobese patient with endometrial carcinoma was not found to be at increased risk of subsequent breast cancer. An unusual occurrence of primary adenocarcinoma of the lung was found ten or more years after treatment for endometrial carcinoma. This increase was not associated with cigarette smoking.

Breast Neoplasms↗
PubMed1981

Epidemiologic study of primary intracranial neoplasms.

The incidence of primary intracranial neoplasms in Rochester, Minn, from 1935 through 1977 is reviewed with regard to whether the tumor was diagnosed because of symptoms arising before death or was found incidentally at autopsy. Among males, the overall age-adjusted incidence rate of cases diagnosed before death was 8.3 per 100,000 population per year, which included a rate of 4.0 for gliomas, 1.2 for meningiomas, and 1.5 for pituitary tumors. Among females, the comparable overall rate was 10.1; that included a rate of 4.1 for gliomas, 2.6 for meningiomas, and 1.7 for pituitary tumors. Of all autopsies on subjects aged 55 years and over, about 1% confirmed or discovered gliomas and slightly more than 1% confirmed or discovered meningiomas.

Adenoma↗
PubMed1980

Carcinoma of the endometrium: stage I.

During the 10-year period ending December, 1972, 577 patients with Stage I endometrial cancer received their primary treatment at the Mayo Clinic. The average age of the group was 60.8 years. The higher-grade lesions were found in older individuals. The data did not show that high grade was related to age at menopause. The initial therapy was total abdominal hysterectomy and bilateral salpingo-oophorectomy. The absolute survival at 5 years was 92.7% for Stage IAG1, 86.5% for IAG2, 68.2% for IAG3, 89.6% for IBG1, 76.4% for IBG2, and 62.9% for IBG3.

Adenocarcinoma↗
PubMed1980

Seizures after head trauma: a population study.

A cohort of 2747 patients with head injuries was followed for 28,176 person-years to determine the magnitude and duration of the risk of posttraumatic seizures. Injuries were classified as severe (brain contusion, intracerebral or intracranial hematoma, or 24 hours of eight unconsciousness of amnesia), moderate (skull fracture or 30 minutes to 24 hours of unconsciousness or amnesia), and mild (briefer unconsciousness or amnesia). The risk of posttraumatic seizures after severe injury was 7.1% within 1 year and 11.5% in 5 years, after moderate injury the risk was 0.7 and 1.6%, and after mild injury the risk was 0.1 and 0.6%. The incidence of seizures after mild head injuries was not significantly greater than in the general population.

Adolescent↗
PubMed1980

The incidence, causes, and secular trends of head trauma in Olmsted County, Minnesota, 1935-1974.

Records in the Mayo Clinic linkage system were reviewed to determine the incidence of head trauma in Olmsted County, Minnesota, from 1935-1974. Minimum criteria for inclusion--loss of consciousness, posttraumatic amnesia, or skull fracture--were met by 3587 cases. During the decade from 1965-1974, the age-adjusted incidence rates per 100,000 population were 270 in males and 116 in females. The rate was highest--658--in males aged 15 to 24, but it was at least 50 in all age and sex groups. Major causes of head injury were automobile accidents (37%) and falls (29%). The incidence of head injuries related to automobiles and recreation has been increasing, whereas most other categories have remained stable or have declined. Of all cases, 446 were fatal, the average annual incidence being 32 per 100,000 in males and 9 per 100,000 in females. Among the groups at high risk of head trauma are those who have had head trauma previously.

Adolescent↗
PubMed1980

Clinicopathologic review of 118 granulosa and 82 theca cell tumors.

The clinical course and histologic features of 118 granulosa cell tumors and 82 theca cell tumors were reviewed. Although the 2 cell types are related, important differences exist in their behavior. Theca cell tumors (TCTs) are virtually benign, while granulosa cell tumors (GCTs) exhibit less malignant activity than most ovarian carcinomas. Characteristically detected at an early stage, GCTs may recur locally years after the initial diagnosis. Survival figures depend on tumor stage. Recurrence of GCTs is associated with a high mortality rate. The cornerstone of treatment is total abdominal hysterectomy and bilateral salpingo-oophorectomy, regardless of age. Adjuvant radiation or chemotherapy may be helpful when lesions are higher than stage lai. Therapy for recurrence usually requires operative excision combined with radiation, chemotherapy, or both.

Adolescent↗
PubMed1979

Ovarian cancer: incidence and case-control study.

The incidence of ovarian cancer in Rochester, Minnesota over the 40-year period 1935 through 1974 was determined; and risk factors for epithelial ovarian cancer occurring in Rochester from 1945 to 1974 were examined in 116 patients and 464 controls. Among the characteristics studied, only nulliparity was found to be a significant risk factor--relative risk 1.8. Other suspected risk factors--including hypertension, obesity, age at menopause, prior therapeutic pelvic radiation, and prior exposure to exogenous estrogen--were found not to differ significantly between patients and controls. The ovarian cancer patients were found to have a significantly lower frequency of prior hysterectomy and of unilateral oophorectomy than the control group. Thus out data show that hysterectomy, even when one or both ovaries are preserved, is associated with a lower risk of subsequent ovarian cancer.

Adolescent↗
PubMed1979

Pituitary adenoma and oral contraceptives: a case-control study.

A search of the centralized data resource available at the Mayo Clinic for all cases of pituitary adenoma diagnosed in the population of Olmstead County, Minnesota, disclosed an increasing incidence of this tumor in women of childbearing age. The sex, age, and temporal relationships suggest that, if this increase is real, oral contraceptives should be considered as one of the possible etiologic factors. A case-control study, however, did not reveal an association of prior use of oral contraceptives with pituitary tumor--relative risk, 0.5; 95% confidence interval, 0.1 to 2.2. No association was found with other possible risk factors, i.e., prior head injury, radiation therapy, seizures, and smoking. Thus, unless other etiologic agents can be identified, it appears that the increasing incidence is due to advances in diagnostic and surgical technology rather than to a specific etiologic factor.

Adenoma↗
PubMed1979

Do anticonvulsants reduce the efficacy of oral contraceptives?

Women in our area with epilepsy who were also taking oral contraceptives were identified. Of 82 patients taking oral contraceptives, 41 had used both anticonvulsants and oral contraceptives for a total of 955 months. Three documented oral contraceptive (pill) failures occurred during this period, whereas the expected number of 0.12 (relative risk, 25; 95% confience interval, 5 to 73). No pill failures were observed in 2,278 months among women with epilepsy who were taking oral contraceptives but who were not taking anticonvulsants at this time. Thus our data support the suggestion that there is an increased rate of pill failure among women taking anticonvulsants. In view of this diminished effectiveness, the advisability of using oral contraceptives rather than one of the other forms of contraception when anticonvulsant medication is being used concurrently may need to be reevaluated.

Anticonvulsants↗
PubMed1979

Remission of seizures and relapse in patients with epilepsy.

In a longitudinal study of patients with epilepsy in Rochester, Minnesota, we found that the probability of being in remission (at least 5 consecutive years seizure-free, and continuing) at 20 years after diagnosis was 70%. The rates for remission we encountered were generally higher than those previously reported. We believe that the better prognosis in our series results from inclusion of all incidence cases in a defined population, beginning at the initial diagnosis of epilepsy. Prognosis for remission of epilepsy is poor in patients with associated neurologic dysfunction identified from birth. Patients with idiopathic seizures and survivors of postnatally acquired epilepsy have better prospects for eventual remission. The probability of remission is highest in patients with generalized-onset seizures diagnosed before 10 years of age. Prognosis is less favorable for those with partial complex seizures and adult-onset epilepsy.

Adolescent↗
PubMed1979

The risk of epilepsy following febrile convulsions.

A cohort of 666 children who had convulsions with fever were followed to determine the risks of subsequent epilepsy. High risks were found in children with preexisting cerebral palsy or mental retardation. Other major risk factors were atypical features of the febrile convulsions (such as focal seizures) and duration of febrile seizures for 10 minuts or more. The risk of developing epilepsy by age 20 was about 6 percent for all children who had experienced febrile convulsions. However, this risk figure consisted of a combination of 2.5 percent of children without prior neurologic disorder or atypical or prolonged seizures, and 17 percent of those with such complications.

Age Factors↗
PubMed1979

Head trauma and subsequent brain tumors.

A long term study of 2,953 persons with 29,859 person-years of follow-up after head injury provided an opportunity to investigate the long-debated association between head trauma and subsequent intracranial tumor. In this series the observed number of cases of subsequent brain tumor did not differ from the number we expected. Because brain tumors are relatively rare, the results of this large series cannot absolutely refute the possibility that head trauma predisposes to brain tumor, but the individual risk is very small, and the weight of evidence does not support an etiological association. The occurrence of subsequent brain tumors in this series was not associated with the severity or location of the head injury. Head trauma does not seem to be a significant etiological factor in meningioma; that tumor has a higher incidence in females, whereas males have 2- to 3-fold greater incidence of head trauma. If any association between head trauma and subsequent brain tumor does exist, it is extremely small or occurs only in the presence of other factors, which themselves must be rare.

Adult↗